Concentric Rings K-space Trajectory for Hyperpolarized (13)C MR Spectroscopic Imaging

Overview

Journal Magn Reson Med

Publisher Wiley

Specialty Radiology

Date 2014 Dec 24

PMID 25533653

Citations 24

Authors

Wenwen Jiang

Michael Lustig

Peder E Z Larson

Affiliations

Soon will be listed here.

Abstract

Purpose: To develop a robust and rapid imaging technique for hyperpolarized (13)C MR Spectroscopic Imaging and investigate its performance.

Methods: A concentric rings readout trajectory with constant angular velocity is proposed for hyperpolarized (13)C spectroscopic imaging and its properties are analyzed. Quantitative analyses of design tradeoffs are presented for several imaging scenarios. The first application of concentric rings on (13)C phantoms and in vivo animal hyperpolarized (13)C MR Spectroscopic Imaging studies were performed to demonstrate the feasibility of the proposed method. Finally, a parallel imaging accelerated concentric rings study is presented.

Results: The concentric rings MR Spectroscopic Imaging trajectory has the advantages of acquisition timesaving compared to echo-planar spectroscopic imaging. It provides sufficient spectral bandwidth with relatively high efficiency compared to echo-planar spectroscopic imaging and spiral techniques. Phantom and in vivo animal studies showed good image quality with half the scan time and reduced pulsatile flow artifacts compared to echo-planar spectroscopic imaging. Parallel imaging accelerated concentric rings showed advantages over Cartesian sampling in g-factor simulations and demonstrated aliasing-free image quality in a hyperpolarized (13)C in vivo study.

Conclusion: The concentric rings trajectory is a robust and rapid imaging technique that fits very well with the speed, bandwidth, and resolution requirements of hyperpolarized (13)C MR Spectroscopic Imaging.

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References

Gordon J, Niles D, Fain S, Johnson K . Joint spatial-spectral reconstruction and k-t spirals for accelerated 2D spatial/1D spectral imaging of 13C dynamics. Magn Reson Med. 2013; 71(4):1435-45. PMC: 4011726. DOI: 10.1002/mrm.24796. View

Josan S, Hurd R, Park J, Yen Y, Watkins R, Pfefferbaum A . Dynamic metabolic imaging of hyperpolarized [2-(13) C]pyruvate using spiral chemical shift imaging with alternating spectral band excitation. Magn Reson Med. 2013; 71(6):2051-8. PMC: 3849119. DOI: 10.1002/mrm.24871. View

Zhao L, Mulkern R, Tseng C, Williamson D, Patz S, Kraft R . Gradient-echo imaging considerations for hyperpolarized 129Xe MR. J Magn Reson B. 1996; 113:179-83. View

Bernstein M, Zhou X, Polzin J, King K, Ganin A, Pelc N . Concomitant gradient terms in phase contrast MR: analysis and correction. Magn Reson Med. 1998; 39(2):300-8. DOI: 10.1002/mrm.1910390218. View

Breuer F, Kannengiesser S, Blaimer M, Seiberlich N, Jakob P, Griswold M . General formulation for quantitative G-factor calculation in GRAPPA reconstructions. Magn Reson Med. 2009; 62(3):739-46. DOI: 10.1002/mrm.22066. View

Pruessmann K, Weiger M, Scheidegger M, Boesiger P . SENSE: sensitivity encoding for fast MRI. Magn Reson Med. 1999; 42(5):952-62. View

Yen Y, Kohler S, Chen A, Tropp J, Bok R, Wolber J . Imaging considerations for in vivo 13C metabolic mapping using hyperpolarized 13C-pyruvate. Magn Reson Med. 2009; 62(1):1-10. PMC: 2782538. DOI: 10.1002/mrm.21987. View

Mayer D, Levin Y, Hurd R, Glover G, Spielman D . Fast metabolic imaging of systems with sparse spectra: application for hyperpolarized 13C imaging. Magn Reson Med. 2006; 56(4):932-7. DOI: 10.1002/mrm.21025. View

Furuyama J, Wilson N, Thomas M . Spectroscopic imaging using concentrically circular echo-planar trajectories in vivo. Magn Reson Med. 2011; 67(6):1515-22. DOI: 10.1002/mrm.23184. View

10.

Uecker M, Lai P, Murphy M, Virtue P, Elad M, Pauly J . ESPIRiT--an eigenvalue approach to autocalibrating parallel MRI: where SENSE meets GRAPPA. Magn Reson Med. 2013; 71(3):990-1001. PMC: 4142121. DOI: 10.1002/mrm.24751. View

11.

Kwon K, Wu H, Shin T, Cukur T, Lustig M, Nishimura D . Three-dimensional magnetization-prepared imaging using a concentric cylinders trajectory. Magn Reson Med. 2013; 71(5):1700-10. PMC: 4056679. DOI: 10.1002/mrm.24823. View

12.

Ramirez M, Lee J, Walker C, Sandulache V, Hennel F, Lai S . Radial spectroscopic MRI of hyperpolarized [1-(13) C] pyruvate at 7 tesla. Magn Reson Med. 2013; 72(4):986-95. PMC: 4007384. DOI: 10.1002/mrm.25004. View

13.

Kurhanewicz J, Vigneron D, Brindle K, Chekmenev E, Comment A, Cunningham C . Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research. Neoplasia. 2011; 13(2):81-97. PMC: 3033588. DOI: 10.1593/neo.101102. View

14.

Tsai C, Nishimura D . Reduced aliasing artifacts using variable-density k-space sampling trajectories. Magn Reson Med. 2000; 43(3):452-8. DOI: 10.1002/(sici)1522-2594(200003)43:3<452::aid-mrm18>3.0.co;2-b. View

15.

Tropp J, Lupo J, Chen A, Calderon P, McCune D, Grafendorfer T . Multi-channel metabolic imaging, with SENSE reconstruction, of hyperpolarized [1-(13)C] pyruvate in a live rat at 3.0 tesla on a clinical MR scanner. J Magn Reson. 2010; 208(1):171-7. PMC: 3387549. DOI: 10.1016/j.jmr.2010.10.007. View

16.

Adalsteinsson E, Irarrazabal P, Topp S, Meyer C, Macovski A, Spielman D . Volumetric spectroscopic imaging with spiral-based k-space trajectories. Magn Reson Med. 1998; 39(6):889-98. DOI: 10.1002/mrm.1910390606. View

17.

Metzger G, Hu X . Application of interlaced Fourier transform to echo-planar spectroscopic imaging. J Magn Reson. 1997; 125(1):166-70. DOI: 10.1006/jmre.1997.1114. View

18.

Wiesinger F, Weidl E, Menzel M, Janich M, Khegai O, Glaser S . IDEAL spiral CSI for dynamic metabolic MR imaging of hyperpolarized [1-13C]pyruvate. Magn Reson Med. 2011; 68(1):8-16. DOI: 10.1002/mrm.23212. View

19.

Pipe J, Ahunbay E, Menon P . Effects of interleaf order for spiral MRI of dynamic processes. Magn Reson Med. 1999; 41(2):417-22. DOI: 10.1002/(sici)1522-2594(199902)41:2<417::aid-mrm29>3.0.co;2-w. View

20.

Mansfield P . Spatial mapping of the chemical shift in NMR. Magn Reson Med. 1984; 1(3):370-86. DOI: 10.1002/mrm.1910010308. View