Insulin-like Growth Factor 2 and Short-range Stimulatory Loops in Control of Human Placental Growth

Overview

Journal EMBO J

Specialties Biotechnology
Molecular Biology

Date 1989 Jul 1

PMID 2551671

Citations 18

Authors

R Ohlsson

L Holmgren

A Glaser

A Szpecht

Affiliations

Soon will be listed here.

Abstract

Substructures of the first-trimester human placenta (within 3 months post-conception) display 'pseudo-malignant' properties. We show here, by in situ hybridization, that the insulin-like growth factor 2 (IGF-2) gene expression is particularly active in the cytotrophoblasts, which dominate these structures. Because the majority of placental IGF-2 mRNA is polysomal in extracts of first-trimester placenta, the spatial pattern of IGF-2 transcripts generally also defines the pattern of IGF-2 production. In primary trophoblast cultures, rendered quiescent by serum starvation. IGF-2 performs as a human embryonic growth factor by activating cell cycle entry/progression. Although both type 1 and 2 IGF receptor mRNAs can be found co-distributed with IGF-2 mRNA during placental development (supporting an autocrine role for IGF-2), these occasional patterns are confined to cytotrophoblasts with low proliferative potential. The reciprocity in ligand and receptor expression patterns are discussed in terms of rate-limiting steps in the involvement of IGF-2 in the proliferative phenotype of the early human placenta.

Citing Articles

Roles of insulin-like growth factor II in regulating female reproductive physiology.

Muhammad T, Li M, Wang J, Huang T, Zhao S, Zhao H Sci China Life Sci. 2020; 63(6):849-865.

PMID: 32291558 DOI: 10.1007/s11427-019-1646-y.

Explant culture: An advantageous method for isolation of mesenchymal stem cells from human tissues.

Hendijani F Cell Prolif. 2017; 50(2).

PMID: 28144997 PMC: 6529062. DOI: 10.1111/cpr.12334.

Data Mining of Determinants of Intrauterine Growth Retardation Revisited Using Novel Algorithms Generating Semantic Maps and Prototypical Discriminating Variable Profiles.

Buscema M, Grossi E, Montanini L, Street M PLoS One. 2015; 10(7):e0126020.

PMID: 26158499 PMC: 4497659. DOI: 10.1371/journal.pone.0126020.

Differentiation in neuroblastoma: diffusion-limited hypoxia induces neuro-endocrine secretory protein 55 and other markers of a chromaffin phenotype.

Hedborg F, Fischer-Colbrie R, Ostlin N, Sandstedt B, Tran M, Maxwell P PLoS One. 2010; 5(9).

PMID: 20862257 PMC: 2941466. DOI: 10.1371/journal.pone.0012825.

Placental determinants of fetal growth: identification of key factors in the insulin-like growth factor and cytokine systems using artificial neural networks.

Street M, Grossi E, Volta C, Faleschini E, Bernasconi S BMC Pediatr. 2008; 8:24.

PMID: 18559101 PMC: 2438355. DOI: 10.1186/1471-2431-8-24.

References

Goustin A, Rydnert J, Wahlstrom T, BJERSING L, Stehelin D, Ohlsson R . Spatial and temporal pattern of cellular myc oncogene expression in developing human placenta: implications for embryonic cell proliferation. Cell. 1984; 38(2):585-96. DOI: 10.1016/0092-8674(84)90513-0. View

Scott J, Cowell J, Robertson M, Priestley L, Wadey R, Hopkins B . Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues. Nature. 1985; 317(6034):260-2. DOI: 10.1038/317260a0. View

Dafgard E, Bajaj M, Honegger A, Pitts J, Wood S, Blundell T . The conformation of insulin-like growth factors: relationships with insulins. J Cell Sci Suppl. 1985; 3:53-64. DOI: 10.1242/jcs.1985.supplement_3.6. View

Ullrich A, Gray A, Tam A, Tsubokawa M, Collins C, Henzel W . Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J. 1986; 5(10):2503-12. PMC: 1167146. DOI: 10.1002/j.1460-2075.1986.tb04528.x. View

Ohlsson R . myc expression in vivo during human embryogenesis. Curr Top Microbiol Immunol. 1986; 132:272-9. DOI: 10.1007/978-3-642-71562-4_41. View

MORGAN D, Edman J, Standring D, Fried V, Smith M, Roth R . Insulin-like growth factor II receptor as a multifunctional binding protein. Nature. 1987; 329(6137):301-7. DOI: 10.1038/329301a0. View

Gray A, Tam A, Dull T, Hayflick J, Pintar J, Cavenee W . Tissue-specific and developmentally regulated transcription of the insulin-like growth factor 2 gene. DNA. 1987; 6(4):283-95. DOI: 10.1089/dna.1987.6.283. View

Smeland E, Beiske K, Ek B, Watt R, Blomhoff H, Godal T . Regulation of c-myc transcription and protein expression during activation of normal human B cells. Exp Cell Res. 1987; 172(1):101-9. DOI: 10.1016/0014-4827(87)90097-8. View

Tally M, Enberg G, Li C, Hall K . The specificity of the human IGF-2 receptor. Biochem Biophys Res Commun. 1987; 147(3):1206-12. DOI: 10.1016/s0006-291x(87)80198-5. View

10.

Meyuhas O, Thompson Jr E, PERRY R . Glucocorticoids selectively inhibit translation of ribosomal protein mRNAs in P1798 lymphosarcoma cells. Mol Cell Biol. 1987; 7(8):2691-9. PMC: 367885. DOI: 10.1128/mcb.7.8.2691-2699.1987. View

11.

Ohlsson R . Cancer genes, proto-oncogenes, and development. Exp Cell Res. 1987; 173(1):1-16. DOI: 10.1016/0014-4827(87)90327-2. View

12.

Greenberg M, Ziff E . Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature. 1984; 311(5985):433-8. DOI: 10.1038/311433a0. View

13.

Schofield P, Tate V . Regulation of human IGF-II transcription in fetal and adult tissues. Development. 1987; 101(4):793-803. DOI: 10.1242/dev.101.4.793. View

14.

Goustin A, Betsholtz C, Persson H, Rydnert J, Bywater M, Holmgren G . Coexpression of the sis and myc proto-oncogenes in developing human placenta suggests autocrine control of trophoblast growth. Cell. 1985; 41(1):301-12. DOI: 10.1016/0092-8674(85)90083-2. View

15.

Rydnert J, Goustin A, Larsson E, Betsholtz C, Ohlsson R . Cell-type-specific pattern of myc protooncogene expression in developing human embryos. Proc Natl Acad Sci U S A. 1985; 82(15):5050-4. PMC: 390496. DOI: 10.1073/pnas.82.15.5050. View

16.

Kliman H, Nestler J, Sermasi E, Sanger J, Strauss 3rd J . Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae. Endocrinology. 1986; 118(4):1567-82. DOI: 10.1210/endo-118-4-1567. View