Cardiac Adipose Tissue and Its Relationship to Diabetes Mellitus and Cardiovascular Disease

Overview

Journal World J Diabetes

Publisher Baishideng Publishing Group

Specialty Endocrinology

Date 2014 Dec 17

PMID 25512789

Citations 23

Authors

Adam M Noyes

Kirandeep Dua

Ramprakash Devadoss

Lovely Chhabra

Affiliations

Soon will be listed here.

Abstract

Type-2 diabetes mellitus (T2DM) plays a central role in the development of cardiovascular disease (CVD). However, its relationship to epicardial adipose tissue (EAT) and pericardial adipose tissue (PAT) in particular is important in the pathophysiology of coronary artery disease. Owing to its close proximity to the heart and coronary vasculature, EAT exerts a direct metabolic impact by secreting proinflammatory adipokines and free fatty acids, which promote CVD locally. In this review, we have discussed the relationship between T2DM and cardiac fat deposits, particularly EAT and PAT, which together exert a big impact on the cardiovascular health.

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