Helicobacter Pylori Genetic Diversity and Gastro-duodenal Diseases in Malaysia

Overview

Journal Sci Rep

Specialty Science

Date 2014 Dec 16

PMID 25503415

Citations 10

Authors

Selva Perumal Gunaletchumy

Indran Seevasant

Mun Hua Tan

Laurence J Croft

Hazel M Mitchell

Khean Lee Goh

Mun Fai Loke

Jamuna Vadivelu

Affiliations

Soon will be listed here.

Abstract

Helicobacter pylori infection results in diverse clinical conditions ranging from chronic gastritis and ulceration to gastric adenocarcinoma. Among the multiethnic population of Malaysia, Indians consistently have a higher H. pylori prevalence as compared with Chinese and Malays. Despite the high prevalence of H. pylori, Indians have a relatively low incidence of peptic ulcer disease and gastric cancer. In contrast, gastric cancer and peptic ulcer disease incidence is high in Chinese. H. pylori strains from Chinese strains predominantly belong to the hspEAsia subpopulation while Indian/Malay strains mainly belong to the hspIndia subpopulation. By comparing the genome of 27 Asian strains from different subpopulations, we identified six genes associated with risk of H. pylori-induced peptic ulcer disease and gastric cancer. This study serves as an important foundation for future studies aiming to understand the role of bacterial factors in H. pylori-induced gastro-duodenal diseases.

Citing Articles

The global prevalence of gastric cancer in Helicobacter pylori-infected individuals: a systematic review and meta-analysis.

Shirani M, Pakzad R, Haddadi M, Akrami S, Asadi A, Kazemian H BMC Infect Dis. 2023; 23(1):543.

PMID: 37598157 PMC: 10439572. DOI: 10.1186/s12879-023-08504-5.

Changes in Calprotectin (S100A8-A9) and Aldolase in the Saliva of Horses with Equine Gastric Ulcer Syndrome.

Munoz-Prieto A, Contreras-Aguilar M, Ceron J, Ayala de la Pena I, Martin-Cuervo M, Eckersall P Animals (Basel). 2023; 13(8).

PMID: 37106929 PMC: 10135270. DOI: 10.3390/ani13081367.

Genomic diversity of populations from different regions of the human stomach.

Wilkinson D, Dickins B, Robinson K, Winter J Gut Microbes. 2022; 14(1):2152306.

PMID: 36469575 PMC: 9728471. DOI: 10.1080/19490976.2022.2152306.

Antimicrobial resistance patterns and genetic elements associated with the antibiotic resistance of Helicobacter pylori strains from Shanghai.

Liu Y, Wang S, Yang F, Chi W, Ding L, Liu T Gut Pathog. 2022; 14(1):14.

PMID: 35354484 PMC: 8966258. DOI: 10.1186/s13099-022-00488-y.

Time trends in the prevalence of infection in patients with peptic ulcer disease: a single-center retrospective study in Shanghai.

Zhang W, Liang X, Chen X, Ge Z, Lu H J Int Med Res. 2021; 49(10):3000605211051167.

PMID: 34686094 PMC: 8674481. DOI: 10.1177/03000605211051167.

References

Goh K . Epidemiology of Helicobacter pylori infection in Malaysia--observations in a multiracial Asian population. Med J Malaysia. 2010; 64(3):187-92. View

Chalker A, Minehart H, Hughes N, Koretke K, Lonetto M, Brinkman K . Systematic identification of selective essential genes in Helicobacter pylori by genome prioritization and allelic replacement mutagenesis. J Bacteriol. 2001; 183(4):1259-68. PMC: 94999. DOI: 10.1128/JB.183.4.1259-1268.2001. View

You Y, Liu L, Zhang M, Han X, He L, Zhu Y . Genome sequences of three Helicobacter pylori strains isolated from atrophic gastritis and gastric ulcer patients in China. J Bacteriol. 2012; 194(22):6314-5. PMC: 3486401. DOI: 10.1128/JB.01399-12. View

Blaser M, Atherton J . Helicobacter pylori persistence: biology and disease. J Clin Invest. 2004; 113(3):321-33. PMC: 324548. DOI: 10.1172/JCI20925. View

Azuma T, Yamazaki S, Yamakawa A, Ohtani M, Muramatsu A, Suto H . Association between diversity in the Src homology 2 domain--containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer. J Infect Dis. 2004; 189(5):820-7. DOI: 10.1086/381782. View

Ahmed N, Tenguria S, Nandanwar N . Helicobacter pylori--a seasoned pathogen by any other name. Gut Pathog. 2009; 1:24. PMC: 2806874. DOI: 10.1186/1757-4749-1-24. View

Roper J, Francois F, Shue P, Mourad M, Pei Z, de Perez A . Leptin and ghrelin in relation to Helicobacter pylori status in adult males. J Clin Endocrinol Metab. 2008; 93(6):2350-7. PMC: 2435636. DOI: 10.1210/jc.2007-2057. View

Conteduca V, Sansonno D, Lauletta G, Russi S, Ingravallo G, Dammacco F . H. pylori infection and gastric cancer: state of the art (review). Int J Oncol. 2012; 42(1):5-18. DOI: 10.3892/ijo.2012.1701. View

Zhu Y, Zheng S, Du Q, Qian K, Fang P . Characterization of CagA variable region of Helicobacter pylori isolates from Chinese patients. World J Gastroenterol. 2005; 11(6):880-4. PMC: 4250602. DOI: 10.3748/wjg.v11.i6.880. View

10.

Blaser M . Who are we? Indigenous microbes and the ecology of human diseases. EMBO Rep. 2006; 7(10):956-60. PMC: 1618379. DOI: 10.1038/sj.embor.7400812. View

11.

Goh K, Parasakthi N . The racial cohort phenomenon: seroepidemiology of Helicobacter pylori infection in a multiracial South-East Asian country. Eur J Gastroenterol Hepatol. 2001; 13(2):177-83. DOI: 10.1097/00042737-200102000-00014. View

12.

You Y, He L, Zhang M, Fu J, Gu Y, Zhang B . Comparative genomics of Helicobacter pylori strains of China associated with different clinical outcome. PLoS One. 2012; 7(6):e38528. PMC: 3368837. DOI: 10.1371/journal.pone.0038528. View

13.

Jones K, Joo Y, Jang S, Yoo Y, Lee H, Chung I . Polymorphism in the CagA EPIYA motif impacts development of gastric cancer. J Clin Microbiol. 2009; 47(4):959-68. PMC: 2668329. DOI: 10.1128/JCM.02330-08. View

14.

Fock K, Talley N, Moayyedi P, Hunt R, Azuma T, Sugano K . Asia-Pacific consensus guidelines on gastric cancer prevention. J Gastroenterol Hepatol. 2008; 23(3):351-65. DOI: 10.1111/j.1440-1746.2008.05314.x. View

15.

Rehvathy V, Tan M, Gunaletchumy S, Teh X, Wang S, Baybayan P . Multiple Genome Sequences of Helicobacter pylori Strains of Diverse Disease and Antibiotic Resistance Backgrounds from Malaysia. Genome Announc. 2013; 1(5). PMC: 3778195. DOI: 10.1128/genomeA.00687-13. View

16.

Aziz R, Bartels D, Best A, DeJongh M, Disz T, Edwards R . The RAST Server: rapid annotations using subsystems technology. BMC Genomics. 2008; 9:75. PMC: 2265698. DOI: 10.1186/1471-2164-9-75. View

17.

Falush D, Wirth T, Linz B, Pritchard J, Stephens M, Kidd M . Traces of human migrations in Helicobacter pylori populations. Science. 2003; 299(5612):1582-5. DOI: 10.1126/science.1080857. View

18.

Kim S, Lee Y, Kim H, Blaser M . Helicobacter pylori CagA transfection of gastric epithelial cells induces interleukin-8. Cell Microbiol. 2005; 8(1):97-106. DOI: 10.1111/j.1462-5822.2005.00603.x. View

19.

Tay C, Mitchell H, Dong Q, Goh K, Dawes I, Lan R . Population structure of Helicobacter pylori among ethnic groups in Malaysia: recent acquisition of the bacterium by the Malay population. BMC Microbiol. 2009; 9:126. PMC: 2708179. DOI: 10.1186/1471-2180-9-126. View

20.

Kusters J, Van Vliet A, Kuipers E . Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev. 2006; 19(3):449-90. PMC: 1539101. DOI: 10.1128/CMR.00054-05. View