Protecting the Mitochondrial Powerhouse

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2014 Dec 16

PMID 25499735

Citations 157

Authors

Morten Scheibye-Knudsen

Evandro F Fang

Deborah L Croteau

David M Wilson 3rd

Vilhelm A Bohr

Affiliations

Soon will be listed here.

Abstract

Mitochondria are the oxygen-consuming power plants of cells. They provide a critical milieu for the synthesis of many essential molecules and allow for highly efficient energy production through oxidative phosphorylation. The use of oxygen is, however, a double-edged sword that on the one hand supplies ATP for cellular survival, and on the other leads to the formation of damaging reactive oxygen species (ROS). Different quality control pathways maintain mitochondria function including mitochondrial DNA (mtDNA) replication and repair, fusion-fission dynamics, free radical scavenging, and mitophagy. Further, failure of these pathways may lead to human disease. We review these pathways and propose a strategy towards a treatment for these often untreatable disorders.

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