Role of Gut Microbiota and Probiotics in Colorectal Cancer: Onset and Progression

Overview

Journal Microorganisms

Specialty Microbiology

Date 2021 Jun 2

PMID 34068653

Citations 32

Authors

Edgar Torres-Maravilla

Anne-Sophie Boucard

Amir Hossein Mohseni

Sedigheh Taghinezhad-S

Naima G Cortes-Perez

Luis G Bermudez-Humaran

Affiliations

Soon will be listed here.

Abstract

The gut microbiota plays an important role in maintaining homeostasis in the human body, and the disruption of these communities can lead to compromised host health and the onset of disease. Current research on probiotics is quite promising and, in particular, these microorganisms have demonstrated their potential for use as adjuvants for the treatment of colorectal cancer. This review addresses the possible applications of probiotics, postbiotics, synbiotics, and next-generation probiotics in colorectal cancer research.

Citing Articles

The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms.

Karam F, El Deghel Y, Iratni R, Dakroub A, Eid A Cell Biochem Biophys. 2025; .

PMID: 39946032 DOI: 10.1007/s12013-025-01683-9.

Effect of probiotics combined with immune checkpoint suppressors and chemotherapeutic agents on digestive system function, intestinal immunity and prognosis in patients with metastatic colorectal carcinoma: a quasi-experimental study.

Wang X, Huang Y, Yang Z, Yang Y, Wei F, Yan M BMC Gastroenterol. 2025; 25(1):38.

PMID: 39871150 PMC: 11773699. DOI: 10.1186/s12876-025-03604-9.

A comprehensive review of probiotics and human health-current prospective and applications.

Sarita B, Samadhan D, Hassan M, Kovaleva E Front Microbiol. 2025; 15():1487641.

PMID: 39834364 PMC: 11743475. DOI: 10.3389/fmicb.2024.1487641.

Deciphering the role of host-gut microbiota crosstalk via diverse sources of extracellular vesicles in colorectal cancer.

Song Y, Shi M, Wang Y Mol Med. 2024; 30(1):200.

PMID: 39501131 PMC: 11536884. DOI: 10.1186/s10020-024-00976-8.

Anticancer Effects of MZY531 Postbiotics in CT26 Colorectal Tumor-Bearing Mice by Regulating Apoptosis and Autophagy.

Zhong B, Zhao Y, Gao L, Yang G, Gao Y, Li F Life (Basel). 2024; 14(10).

PMID: 39459634 PMC: 11509727. DOI: 10.3390/life14101334.

References

Kim M, Vogtmann E, Ahlquist D, Devens M, Kisiel J, Taylor W . Fecal Metabolomic Signatures in Colorectal Adenoma Patients Are Associated with Gut Microbiota and Early Events of Colorectal Cancer Pathogenesis. mBio. 2020; 11(1). PMC: 7029137. DOI: 10.1128/mBio.03186-19. View

Rajilic-Stojanovic M, de Vos W . The first 1000 cultured species of the human gastrointestinal microbiota. FEMS Microbiol Rev. 2014; 38(5):996-1047. PMC: 4262072. DOI: 10.1111/1574-6976.12075. View

Lin P, Li S, Lin H, Shih C . Germinated brown rice combined with and subsp. inhibits colorectal carcinogenesis in rats. Food Sci Nutr. 2019; 7(1):216-224. PMC: 6341155. DOI: 10.1002/fsn3.864. View

Tsoi H, Chu E, Zhang X, Sheng J, Nakatsu G, Ng S . Peptostreptococcus anaerobius Induces Intracellular Cholesterol Biosynthesis in Colon Cells to Induce Proliferation and Causes Dysplasia in Mice. Gastroenterology. 2017; 152(6):1419-1433.e5. DOI: 10.1053/j.gastro.2017.01.009. View

Chagneau C, Garcie C, Bossuet-Greif N, Tronnet S, Brachmann A, Piel J . The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin. mSphere. 2019; 4(5). PMC: 6796968. DOI: 10.1128/mSphere.00414-19. View

De Almeida C, de Camargo M, Russo E, Amedei A . Role of diet and gut microbiota on colorectal cancer immunomodulation. World J Gastroenterol. 2019; 25(2):151-162. PMC: 6337022. DOI: 10.3748/wjg.v25.i2.151. View

Oh N, Joung J, Lee J, Kim Y, Kim Y, Kim S . A synbiotic combination of Lactobacillus gasseri 505 and Cudrania tricuspidata leaf extract prevents hepatic toxicity induced by colorectal cancer in mice. J Dairy Sci. 2020; 103(4):2947-2955. DOI: 10.3168/jds.2019-17411. View

Wilson M, Jiang Y, Villalta P, Stornetta A, Boudreau P, Carra A . The human gut bacterial genotoxin colibactin alkylates DNA. Science. 2019; 363(6428). PMC: 6407708. DOI: 10.1126/science.aar7785. View

Mager L, Wasmer M, Rau T, Krebs P . Cytokine-Induced Modulation of Colorectal Cancer. Front Oncol. 2016; 6:96. PMC: 4835502. DOI: 10.3389/fonc.2016.00096. View

10.

Luan C, Xie L, Yang X, Miao H, Lv N, Zhang R . Dysbiosis of fungal microbiota in the intestinal mucosa of patients with colorectal adenomas. Sci Rep. 2015; 5:7980. PMC: 4648387. DOI: 10.1038/srep07980. View

11.

Boleij A, Schaeps R, Tjalsma H . Association between Streptococcus bovis and colon cancer. J Clin Microbiol. 2009; 47(2):516. PMC: 2643683. DOI: 10.1128/JCM.01755-08. View

12.

Martin R, Miquel S, Ulmer J, Kechaou N, Langella P, Bermudez-Humaran L . Role of commensal and probiotic bacteria in human health: a focus on inflammatory bowel disease. Microb Cell Fact. 2013; 12:71. PMC: 3726476. DOI: 10.1186/1475-2859-12-71. View

13.

Saito S, Kakizaki N, Okuno A, Maekawa T, Tsuji N . subsp. C60 restores T Cell Population in Small Intestinal Lamina Propria in Aged Interleukin-18 Deficient Mice. Nutrients. 2020; 12(11). PMC: 7693701. DOI: 10.3390/nu12113287. View

14.

Shang S, Hua F, Hu Z . The regulation of β-catenin activity and function in cancer: therapeutic opportunities. Oncotarget. 2017; 8(20):33972-33989. PMC: 5464927. DOI: 10.18632/oncotarget.15687. View

15.

Wirbel J, Pyl P, Kartal E, Zych K, Kashani A, Milanese A . Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer. Nat Med. 2019; 25(4):679-689. PMC: 7984229. DOI: 10.1038/s41591-019-0406-6. View

16.

Cuevas-Ramos G, Petit C, Marcq I, Boury M, Oswald E, Nougayrede J . Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells. Proc Natl Acad Sci U S A. 2010; 107(25):11537-42. PMC: 2895108. DOI: 10.1073/pnas.1001261107. View

17.

Jacouton E, Chain F, Sokol H, Langella P, Bermudez-Humaran L . Probiotic Strain BL23 Prevents Colitis-Associated Colorectal Cancer. Front Immunol. 2017; 8:1553. PMC: 5702231. DOI: 10.3389/fimmu.2017.01553. View

18.

Tukenmez U, Aktas B, Aslim B, Yavuz S . The relationship between the structural characteristics of lactobacilli-EPS and its ability to induce apoptosis in colon cancer cells in vitro. Sci Rep. 2019; 9(1):8268. PMC: 6547643. DOI: 10.1038/s41598-019-44753-8. View

19.

Wong S, Zhao L, Zhang X, Nakatsu G, Han J, Xu W . Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice. Gastroenterology. 2017; 153(6):1621-1633.e6. DOI: 10.1053/j.gastro.2017.08.022. View

20.

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M . Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2014; 136(5):E359-86. DOI: 10.1002/ijc.29210. View