A Switch from CD44⁺ Cell to EMT Cell Drives the Metastasis of Prostate Cancer

Overview

Journal Oncotarget

Specialty Oncology

Date 2014 Dec 9

PMID 25483103

Citations 34

Authors

Zhiqun Shang

Qiliang Cai

Minghao Zhang

Shimiao Zhu

Yuan Ma

Libin Sun

Ning Jiang

Jing Tian

Xiaodan Niu

Jiatong Chen

Yinghao Sun

Yuanjie Niu

Affiliations

Soon will be listed here.

Abstract

Epithelial-mesenchymal transition (EMT) has been linked to cancer stem-like (CD44+) cell in the prostate cancer (PCa) metastasis. However, the molecular mechanism remains elusive. Here, we found EMT contributed to metastasis in PCa patients failed in androgen deprivation therapy (ADT). Castration TRAMP model also proved PCa treated with ADT promoted EMT with increased CD44+ stem-like cells. Switched CD44+ cell to EMT cell is a key step for luminal PCa cell metastasis. Our results also suggested ADT might go through promoting TGFβ1-CD44 signaling to enhance swift to EMT. Targeting CD44 with salinomycin and siRNA could inhibit cell transition and decrease PCa invasion. Together, cancer stem-like (CD44+) cells could be the initiator cells of EMT modulated by TGFβ1-CD44 signaling. Combined therapy of ADT with anti-CD44 may become a new potential therapeutic approach to battle later stage PCa.

Citing Articles

Investigating High-risk Factors, Precise Diagnosis, and Treatment of Castration- Resistant Prostate Cancer (CRPC).

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A Narrative Review on CD44's Role in Glioblastoma Invasion, Proliferation, and Tumor Recurrence.

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Pretreatment of prostate cancer cells with salinomycin and Wnt inhibitor increases the efficacy of cabazitaxel by inducing apoptosis and decreasing cancer stem cells.

Serttas R, Erdogan S Med Oncol. 2023; 40(7):194.

PMID: 37264204 DOI: 10.1007/s12032-023-02062-1.

The ADAM9/WISP-1 axis cooperates with osteoblasts to stimulate primary prostate tumor growth and metastasis.

Chang A, Lin L, Chen Y, Chen P, Liu S, Tai H Int J Biol Sci. 2023; 19(3):760-771.

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Adaptation to Hypoxia May Promote Therapeutic Resistance to Androgen Receptor Inhibition in Triple-Negative Breast Cancer.

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