MicroRNAs: New Players in IBD

Overview

Journal Gut

Specialty Gastroenterology

Date 2014 Dec 6

PMID 25475103

Citations 130

Authors

R Kalla

N T Ventham

N A Kennedy

J F Quintana

E R Nimmo

A H Buck

J Satsangi

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs, 18-23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common diseases, including IBDs. This review aims to outline the history, biogenesis and regulation of miRNAs. The role of miRNAs in the development and regulation of the innate and adaptive immune system is discussed, with a particular focus on mechanisms pertinent to IBD and the potential translational applications.

Citing Articles

Human-derived microRNA 21 regulates indole and L-tryptophan biosynthesis transcripts in the gut commensal .

Flanagan K, Gassner K, Lang M, Ozelyte J, Hausmann B, Crepaz D mBio. 2025; 16(3):e0392824.

PMID: 39878512 PMC: 11898669. DOI: 10.1128/mbio.03928-24.

Chronic Gastrointestinal Disorders and miRNA-Associated Disease: An Up-to-Date.

Giammona A, Galuzzi B, Imperia E, Gervasoni C, Remedia S, Restaneo L Int J Mol Sci. 2025; 26(1.

PMID: 39796266 PMC: 11720538. DOI: 10.3390/ijms26010413.

MiR-301b-3p promotes breast cancer development through inhibiting the expression of transforming growth factor-beta receptor 2.

Lou J, Liu X, Xie Y, Wu M, Mao W, Ying X PeerJ. 2024; 12:e18324.

PMID: 39525474 PMC: 11546148. DOI: 10.7717/peerj.18324.

Precision Medicine in Inflammatory Bowel Disease: A Spotlight on Emerging Molecular Biomarkers.

Mestrovic A, Perkovic N, Bozic D, Kumric M, Vilovic M, Bozic J Biomedicines. 2024; 12(7).

PMID: 39062093 PMC: 11274502. DOI: 10.3390/biomedicines12071520.

Emerging concepts in alcohol, infection & immunity: A summary of the 2023 alcohol and immunology research interest group (AIRIG) meeting.

Rutt L, Liu M, Melamed E, Twardy S, Sturgill J, Brenner L Alcohol. 2024; 118:9-16.

PMID: 38582261 PMC: 11179971. DOI: 10.1016/j.alcohol.2024.04.002.

References

Eulalio A, Huntzinger E, Izaurralde E . Getting to the root of miRNA-mediated gene silencing. Cell. 2008; 132(1):9-14. DOI: 10.1016/j.cell.2007.12.024. View

Peltier H, Latham G . Normalization of microRNA expression levels in quantitative RT-PCR assays: identification of suitable reference RNA targets in normal and cancerous human solid tissues. RNA. 2008; 14(5):844-52. PMC: 2327352. DOI: 10.1261/rna.939908. View

Helwak A, Kudla G, Dudnakova T, Tollervey D . Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding. Cell. 2013; 153(3):654-65. PMC: 3650559. DOI: 10.1016/j.cell.2013.03.043. View

Saunders M, Liang H, Li W . Human polymorphism at microRNAs and microRNA target sites. Proc Natl Acad Sci U S A. 2007; 104(9):3300-5. PMC: 1805605. DOI: 10.1073/pnas.0611347104. View

Schwarz D, Hutvagner G, Haley B, Zamore P . Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways. Mol Cell. 2002; 10(3):537-48. DOI: 10.1016/s1097-2765(02)00651-2. View

Adams A, Kennedy N, Hansen R, Ventham N, OLeary K, Drummond H . Two-stage genome-wide methylation profiling in childhood-onset Crohn's Disease implicates epigenetic alterations at the VMP1/MIR21 and HLA loci. Inflamm Bowel Dis. 2014; 20(10):1784-93. PMC: 4736293. DOI: 10.1097/MIB.0000000000000179. View

Wan G, Zhang X, Langley R, Liu Y, Hu X, Han C . DNA-damage-induced nuclear export of precursor microRNAs is regulated by the ATM-AKT pathway. Cell Rep. 2013; 3(6):2100-12. PMC: 3796289. DOI: 10.1016/j.celrep.2013.05.038. View

Mendell J, Olson E . MicroRNAs in stress signaling and human disease. Cell. 2012; 148(6):1172-87. PMC: 3308137. DOI: 10.1016/j.cell.2012.02.005. View

Ambros V . A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans. Cell. 1989; 57(1):49-57. DOI: 10.1016/0092-8674(89)90171-2. View

10.

Chen Y, Xiao Y, Ge W, Zhou K, Wen J, Yan W . miR-200b inhibits TGF-β1-induced epithelial-mesenchymal transition and promotes growth of intestinal epithelial cells. Cell Death Dis. 2013; 4:e541. PMC: 3613822. DOI: 10.1038/cddis.2013.22. View

11.

Wan G, Xie W, Liu Z, Xu W, Lao Y, Huang N . Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway. Autophagy. 2013; 10(1):70-9. PMC: 4389881. DOI: 10.4161/auto.26534. View

12.

Anderson C, Boucher G, Lees C, Franke A, DAmato M, Taylor K . Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet. 2011; 43(3):246-52. PMC: 3084597. DOI: 10.1038/ng.764. View

13.

Lee Y, Kim M, Han J, Yeom K, Lee S, Baek S . MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 2004; 23(20):4051-60. PMC: 524334. DOI: 10.1038/sj.emboj.7600385. View

14.

Milo R, Itzkovitz S, Kashtan N, Chklovskii D, Alon U . Network motifs: simple building blocks of complex networks. Science. 2002; 298(5594):824-7. DOI: 10.1126/science.298.5594.824. View

15.

Taganov K, Boldin M, Chang K, Baltimore D . NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A. 2006; 103(33):12481-6. PMC: 1567904. DOI: 10.1073/pnas.0605298103. View

16.

Huang Z, Shi T, Zhou Q, Shi S, Zhao R, Shi H . miR-141 Regulates colonic leukocytic trafficking by targeting CXCL12β during murine colitis and human Crohn's disease. Gut. 2013; 63(8):1247-57. DOI: 10.1136/gutjnl-2012-304213. View

17.

Wang L, Liang R, Chim C . Methylation of tumor suppressor microRNAs: lessons from lymphoid malignancies. Expert Rev Mol Diagn. 2012; 12(7):755-65. DOI: 10.1586/erm.12.64. View

18.

Breving K, Esquela-Kerscher A . The complexities of microRNA regulation: mirandering around the rules. Int J Biochem Cell Biol. 2009; 42(8):1316-29. DOI: 10.1016/j.biocel.2009.09.016. View

19.

ODonnell K, Wentzel E, Zeller K, Dang C, Mendell J . c-Myc-regulated microRNAs modulate E2F1 expression. Nature. 2005; 435(7043):839-43. DOI: 10.1038/nature03677. View

20.

Hsu S, Wang B, Kota J, Yu J, Costinean S, Kutay H . Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver. J Clin Invest. 2012; 122(8):2871-83. PMC: 3408748. DOI: 10.1172/JCI63539. View