Pyrrole Alkaloids from the Fruits of Morus Alba

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2014 Dec 4

PMID 25467154

Citations 14

Authors

Seon Beom Kim

Bo Yoon Chang

Bang Yeon Hwang

Sung Yeon Kim

Mi Kyeong Lee

Affiliations

Soon will be listed here.

Abstract

Phytochemical investigation of the fruits of Morus alba afforded seventeen pyrrole alkaloids including five new compounds. The structures of five new pyrrole alkaloids, named morroles B-F (4, 5, 7, 16 and 17), were determined on the basis of spectroscopic interpretations. 4-[Formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]butanoate (2) was synthesized by chemical reaction but first isolated from nature. Among isolated compounds, compounds 6 and 14 significantly inhibited pancreatic lipase activity.

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