» Articles » PMID: 25461616

The Peopling of the African Continent and the Diaspora into the New World

Overview
Publisher Elsevier
Specialties Biology
Genetics
Date 2014 Dec 3
PMID 25461616
Citations 27
Authors
Affiliations
Soon will be listed here.
Abstract

Africa is the birthplace of anatomically modern humans, and is the geographic origin of human migration across the globe within the last 100,000 years. The history of African populations has consisted of a number of demographic events that have influenced patterns of genetic and phenotypic variation across the continent. With the increasing amount of genomic data and corresponding developments in computational methods, researchers are able to explore long-standing evolutionary questions, expanding our understanding of human history within and outside of Africa. This review will summarize some of the recent findings regarding African demographic history, including the African Diaspora, and will briefly explore their implications for disease susceptibility in populations of African descent.

Citing Articles

A morphometric study of posterior tibial slope differences by sex and ethnicity in a South African population.

Hohmann E, Nel A, Zyl R, Natalie N, Mogale N Surg Radiol Anat. 2025; 47(1):52.

PMID: 39751943 PMC: 11698820. DOI: 10.1007/s00276-024-03551-2.


AncestryGrapher toolkit: Python command-line pipelines to visualize global- and local- ancestry inferences from the RFMIX version 2 software.

Lisi A, Campbell M Bioinformatics. 2024; 40(11).

PMID: 39412440 PMC: 11534077. DOI: 10.1093/bioinformatics/btae616.


Whole-genome sequencing reveals a complex African population demographic history and signatures of local adaptation.

Fan S, Spence J, Feng Y, Hansen M, Terhorst J, Beltrame M Cell. 2023; 186(5):923-939.e14.

PMID: 36868214 PMC: 10568978. DOI: 10.1016/j.cell.2023.01.042.


Community-engaged ancient DNA project reveals diverse origins of 18th-century African descendants in Charleston, South Carolina.

Fleskes R, Cabana G, Gilmore J, Juarez C, Karcher E, Oubre L Proc Natl Acad Sci U S A. 2023; 120(3):e2201620120.

PMID: 36623185 PMC: 9934026. DOI: 10.1073/pnas.2201620120.


A Review of Cancer Genetics and Genomics Studies in Africa.

Rotimi S, Rotimi O, Salhia B Front Oncol. 2021; 10:606400.

PMID: 33659210 PMC: 7917259. DOI: 10.3389/fonc.2020.606400.


References
1.
Quintana-Murci L, Quach H, Harmant C, Luca F, Massonnet B, Patin E . Maternal traces of deep common ancestry and asymmetric gene flow between Pygmy hunter-gatherers and Bantu-speaking farmers. Proc Natl Acad Sci U S A. 2008; 105(5):1596-601. PMC: 2234190. DOI: 10.1073/pnas.0711467105. View

2.
Freedman B, Kopp J, Langefeld C, Genovese G, Friedman D, Nelson G . The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans. J Am Soc Nephrol. 2010; 21(9):1422-6. PMC: 7391383. DOI: 10.1681/ASN.2010070730. View

3.
Schroeder H, OConnell T, Evans J, Shuler K, Hedges R . Trans-Atlantic slavery: isotopic evidence for forced migration to Barbados. Am J Phys Anthropol. 2009; 139(4):547-57. DOI: 10.1002/ajpa.21019. View

4.
Rawlings-Goss R, Campbell M, Tishkoff S . Global population-specific variation in miRNA associated with cancer risk and clinical biomarkers. BMC Med Genomics. 2014; 7:53. PMC: 4159108. DOI: 10.1186/1755-8794-7-53. View

5.
Zakharia F, Basu A, Absher D, Assimes T, Go A, Hlatky M . Characterizing the admixed African ancestry of African Americans. Genome Biol. 2009; 10(12):R141. PMC: 2812948. DOI: 10.1186/gb-2009-10-12-r141. View