Chemoprevention of Oral Cancer by Topical Application of Black Raspberries on High At-risk Mucosa

Overview

Journal Oral Surg Oral Med Oral Pathol Oral Radiol

Publisher Elsevier

Specialties Dentistry
General Surgery

Date 2014 Dec 3

PMID 25457886

Citations 13

Authors

Blake M Warner

Bruce C Casto

Thomas J Knobloch

Brent T Accurso

Christopher M Weghorst

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the preclinical efficacy of topical administration of freeze-dried black raspberries (BRBs) to inhibit the progression of premalignant oral lesions and modulate biomarkers of cancer development in high at-risk mucosa (HARM).

Study Design: Hamster cheek pouches (HCPs) were treated with carcinogen for 6 weeks to initiate a HARM microenvironment. Subsequently, right HCPs were topically administered a BRB suspension in short-term or long-term studies. After 12 weeks, squamous cell carcinoma (SCC) multiplicity, SCC incidence, and cell proliferation rates were evaluated. mRNA expression was measured in short-term treated pouches for selected oral cancer biomarkers.

Results: SCC multiplicity (-41.3%), tumor incidence (-37.1%), and proliferation rate (-6.9%) were reduced in HCPs receiving BRBs. Topical BRBs correlated with an increase in RB1 expression in developing oral lesions.

Conclusions: Topical BRBs inhibit SCC development when targeted to HARM tissues. These results support the translational role of BRBs to prevent oral cancer development in humans.

Citing Articles

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Modulator effect of mangiferin on biochemical characterization in 7,12-dimethylbenz[a]anthracene induced oral cancer in experimental hamsters.

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