The Effect of Resveratrol on the Recurrent Attacks of Gouty Arthritis

Overview

Journal Clin Rheumatol

Publisher Springer

Specialty Rheumatology

Date 2014 Dec 3

PMID 25451618

Citations 24

Authors

Haiyan Chen

Shucong Zheng

Yuankai Wang

Huiqing Zhu

Qiong Liu

Yu Xue

Jianhua Qiu

Hejian Zou

Xiaoxia Zhu

Affiliations

Soon will be listed here.

Abstract

Gouty arthritis is characterized by inflammation induced by monosodium urate (MSU) crystal deposition, which is resulted by an increase of serum urate concentration. The management of gout, especially the recurrent acute attacks of chronic gouty arthritis, is still a problem to be resolved. In this study, we aimed to develop the preventive and therapeutic effect of resveratrol on gouty arthritis. MSU was used to induce gouty arthritis in the foot pad of C57BL/6 mice. Yeast polysaccharide and potassium oxonate were used to induce hyperuricemia in Kunming mice. Resveratrol was intraperitoneal injected to the mice in the treatment group. The pad inflammation and the level of serum uric acid were investigated to estimate the effect of resveratrol in gouty arthritis. Hyperuricemia was significantly detected in the mice treated with yeast polysaccharide and potassium oxonate, and gouty arthritis was successfully induced with MSU in mice. We further identified that resveratrol inhibited pad swelling and pad 99mTc uptake in gouty mice. Moreover, serum uric acid level was also decreased by resveratrol in hyperuricemia mice. This study highlighted that resveratrol might be applied to prevent the recurrent acute attack of gouty arthritis because of its inhibition of articular inflammation and down-regulation of serum uric acid.

Citing Articles

Investigating the mechanisms of resveratrol in the treatment of gouty arthritis through the integration of network pharmacology and metabolics.

Xu X, Yu D, Wang Y, Jiang X, Lu F, Liu S Front Endocrinol (Lausanne). 2024; 15:1438405.

PMID: 39534253 PMC: 11555470. DOI: 10.3389/fendo.2024.1438405.

Potential role of resveratrol in prevention and therapy of diabetic complications: a critical review.

Koushki M, Farahani M, Farrokhi Yekta R, Frazizadeh N, Bahari P, Parsamanesh N Food Nutr Res. 2024; 68.

PMID: 38716357 PMC: 11075469. DOI: 10.29219/fnr.v68.9731.

Neutrophil autophagy induced by monosodium urate crystals facilitates neutrophil extracellular traps formation and inflammation remission in gouty arthritis.

Huang S, Wang Y, Lin S, Guan W, Liang H, Shen J Front Endocrinol (Lausanne). 2023; 14:1071630.

PMID: 37810893 PMC: 10557066. DOI: 10.3389/fendo.2023.1071630.

Resveratrol Protects against Skin Inflammation through Inhibition of Mast Cell, Sphingosine Kinase-1, Stat3 and NF-κB p65 Signaling Activation in Mice.

Carlucci C, Hui Y, Chumanevich A, Robida P, Fuseler J, Sajish M Int J Mol Sci. 2023; 24(7).

PMID: 37047680 PMC: 10095068. DOI: 10.3390/ijms24076707.

Hyperuricemia during Pregnancy Leads to a Preeclampsia-Like Phenotype in Mice.

Luscher B, Schoeberlein A, Surbek D, Baumann M Cells. 2022; 11(22).

PMID: 36429132 PMC: 9688737. DOI: 10.3390/cells11223703.

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