Anti-Inflammatory and Hypouricemic Effect of Bioactive Compounds: Molecular Evidence and Potential Application in the Management of Gout

Overview

Journal Curr Issues Mol Biol

Publisher MDPI

Specialty Molecular Biology

Date 2022 Nov 10

PMID 36354664

Authors

Anna Scanu

Roberto Luisetto

Roberta Ramonda

Paolo Spinella

Paolo Sfriso

Paola Galozzi

Francesca Oliviero

Affiliations

Soon will be listed here.

Abstract

Gout is caused by the deposition of monosodium urate crystals in the joint and represents the most common form of inflammatory arthritis in men. Its prevalence is rising worldwide mainly due to the increase of risk factors associated with the disease, in particular hyperuricemia. Besides gout, hyperuricemia leads to an increased inflammatory state of the body with consequent increased risk of comorbidities such as cardiovascular diseases. Increasing evidence shows that bioactive compounds have a significant role in fighting inflammatory and immune chronic conditions. In gout and hyperuricemia, these molecules can exert their effects at two levels. They can either decrease serum uric acid concentrations or fight inflammation associated with monosodium urate crystals deposits and hyperuricemia. In this view, they might be considered valuable support to the pharmacological therapy and prevention of the disease. This review aims to provide an overview of the beneficial role of bioactive compounds in hyperuricemia, gout development, and inflammatory pathways of the disease.

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References

Lamb K, Lynn A, Russell J, Barker M . Effect of tart cherry juice on risk of gout attacks: protocol for a randomised controlled trial. BMJ Open. 2020; 10(3):e035108. PMC: 7073821. DOI: 10.1136/bmjopen-2019-035108. View

Li X, Jin W, Zhang W, Zheng G . The inhibitory kinetics and mechanism of quercetin-3-O-rhamnoside and chlorogenic acid derived from Smilax china L. EtOAc fraction on xanthine oxidase. Int J Biol Macromol. 2022; 213:447-455. DOI: 10.1016/j.ijbiomac.2022.05.188. View

Mehmood A, Zhao L, Wang C, Hossen I, Raka R, Zhang H . Stevia residue extract increases intestinal uric acid excretion via interactions with intestinal urate transporters in hyperuricemic mice. Food Funct. 2019; 10(12):7900-7912. DOI: 10.1039/c9fo02032b. View

de Souza M, de Paula C, Pereira de Resende M, Grabe-Guimaraes A, de Souza Filho J, Saude-Guimaraes D . Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents. J Ethnopharmacol. 2012; 142(3):845-50. DOI: 10.1016/j.jep.2012.06.012. View

Dhanasekar C, Kalaiselvan S, Rasool M . Morin, a Bioflavonoid Suppresses Monosodium Urate Crystal-Induced Inflammatory Immune Response in RAW 264.7 Macrophages through the Inhibition of Inflammatory Mediators, Intracellular ROS Levels and NF-κB Activation. PLoS One. 2015; 10(12):e0145093. PMC: 4692533. DOI: 10.1371/journal.pone.0145093. View

Shi Y, Wang C, Liu L, Liu Y, Wang X, Hong Y . Antihyperuricemic and nephroprotective effects of resveratrol and its analogues in hyperuricemic mice. Mol Nutr Food Res. 2012; 56(9):1433-44. DOI: 10.1002/mnfr.201100828. View

Xu Y, Cao X, Zhao H, Yang E, Wang Y, Cheng N . Impact of Bee Pollen Polyphenols on Hyperuricemia and Gut Microbiota in Potassium Oxonate-Induced Mice. Nutrients. 2021; 13(8). PMC: 8401623. DOI: 10.3390/nu13082665. View

Liu H, Pan X, Liu B, Gui X, Hu L, Jiang C . Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression. J Neuroinflammation. 2017; 14(1):74. PMC: 5381065. DOI: 10.1186/s12974-017-0849-y. View

Pineda C, Fuentes-Gomez A, Hernandez-Diaz C, Zamudio-Cuevas Y, Fernandez-Torres J, Lopez-Macay A . Animal model of acute gout reproduces the inflammatory and ultrasonographic joint changes of human gout. Arthritis Res Ther. 2015; 17:37. PMC: 4363186. DOI: 10.1186/s13075-015-0550-4. View

10.

Prasongwatana V, Woottisin S, Sriboonlue P, Kukongviriyapan V . Uricosuric effect of Roselle (Hibiscus sabdariffa) in normal and renal-stone former subjects. J Ethnopharmacol. 2008; 117(3):491-5. DOI: 10.1016/j.jep.2008.02.036. View

11.

Biesalski H, Dragsted L, Elmadfa I, Grossklaus R, Muller M, Schrenk D . Bioactive compounds: definition and assessment of activity. Nutrition. 2009; 25(11-12):1202-5. DOI: 10.1016/j.nut.2009.04.023. View

12.

Sato V, Chewchinda S, Parichatikanond W, Vongsak B . and evidence of hypouricemic and anti-inflammatory activities of (Lour.) Corner heartwood extract. J Tradit Complement Med. 2020; 10(1):85-94. PMC: 6957808. DOI: 10.1016/j.jtcme.2019.03.003. View

13.

Yamanaka H, Taniguchi A, Tsuboi H, Kano H, Asami Y . Hypouricaemic effects of yoghurt containing Lactobacillus gasseri PA-3 in patients with hyperuricaemia and/or gout: A randomised, double-blind, placebo-controlled study. Mod Rheumatol. 2018; 29(1):146-150. DOI: 10.1080/14397595.2018.1442183. View

14.

Schlesinger N, Schlesinger M . Previously reported prior studies of cherry juice concentrate for gout flare prophylaxis: comment on the article by Zhang et al. Arthritis Rheum. 2013; 65(4):1135-6. DOI: 10.1002/art.37864. View

15.

Virgen Gen J, Guzman-Geronimo R, Martinez-Flores K, Martinez-Nava G, Fernandez-Torres J, Zamudio-Cuevas Y . Cherry extracts attenuate inflammation and oxidative stress triggered by monosodium urate crystals in THP-1 cells. J Food Biochem. 2020; 44(10):e13403. DOI: 10.1111/jfbc.13403. View

16.

Zhu J, Wang Y, Kong L, Yang C, Zhang X . Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver. J Ethnopharmacol. 2004; 93(1):133-40. DOI: 10.1016/j.jep.2004.03.037. View

17.

Shi Y, Williamson G . Quercetin lowers plasma uric acid in pre-hyperuricaemic males: a randomised, double-blinded, placebo-controlled, cross-over trial. Br J Nutr. 2016; 115(5):800-6. DOI: 10.1017/S0007114515005310. View

18.

Li H, Zhang X, Gu L, Ju Y, Zhou X, Hu M . Anti-Gout Effects of the Medicinal Fungus in Hyperuricaemia and Acute Gouty Arthritis Rat Models. Front Pharmacol. 2022; 12:801910. PMC: 8787200. DOI: 10.3389/fphar.2021.801910. View

19.

Blau L . Cherry diet control for gout and arthritis. Tex Rep Biol Med. 1950; 8(3):309-11. View

20.

Sun R, Kan J, Cai H, Hong J, Jin C, Zhang M . In vitro and in vivo ameliorative effects of polyphenols from purple potato leaves on renal injury and associated inflammation induced by hyperuricemia. J Food Biochem. 2022; 46(2):e14049. DOI: 10.1111/jfbc.14049. View