Self-rated and Informant-rated Everyday Function in Comparison to Objective Markers of Alzheimer's Disease

Overview

Journal Alzheimers Dement

Specialties Neurology
Psychiatry

Date 2014 Dec 3

PMID 25449531

Citations 55

Authors

Alicia D Rueda

Karen M Lau

Naomi Saito

Danielle Harvey

Shannon L Risacher

Paul S Aisen

Ronald C Petersen

Andrew J Saykin

Sarah Tomaszewski Farias

Affiliations

Soon will be listed here.

Abstract

It is recognized that individuals with mild cognitive impairment (MCI) already demonstrate difficulty in aspects of daily functioning, which predicts disease progression. This study examined the relationship between self- versus informant-report of functional ability, and how those reports relate to objective disease measures across the disease spectrum (i.e. cognitively normal, MCI, Alzheimer's disease). A total of 1080 subjects with self- and/or informant-rated Everyday Cognition questionnaires were included. Objective measures included cognitive functioning, structural brain atrophy, cerebrospinal fluid abnormalities, and a marker of amyloid deposition using positron emission tomography with [18F]AV45 (florbetapir). Overall, informant-report was consistently more associated with objective markers of disease than self-report although self-reported functional status may still have some utility in early disease.

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