Pluripotent Stem Cells for Schwann Cell Engineering

Overview

Journal Stem Cell Rev Rep

Publisher Springer

Specialty Cell Biology

Date 2014 Dec 1

PMID 25433863

Citations 16

Authors

Ming-San Ma

Erik Boddeke

Sjef Copray

Affiliations

Soon will be listed here.

Abstract

Tissue engineering of Schwann cells (SCs) can serve a number of purposes, such as in vitro SC-related disease modeling, treatment of peripheral nerve diseases or peripheral nerve injury, and, potentially, treatment of CNS diseases. SCs can be generated from autologous stem cells in vitro by recapitulating the various stages of in vivo neural crest formation and SC differentiation. In this review, we survey the cellular and molecular mechanisms underlying these in vivo processes. We then focus on the current in vitro strategies for generating SCs from two sources of pluripotent stem cells, namely embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Different methods for SC engineering from ESCs and iPSCs are reviewed and suggestions are proposed for optimizing the existing protocols. Potential safety issues regarding the clinical application of iPSC-derived SCs are discussed as well. Lastly, we will address future aspects of SC engineering.

Citing Articles

Development and In Vitro Differentiation of Schwann Cells.

Horner S, Couturier N, Gueiber D, Hafner M, Rudolf R Cells. 2022; 11(23).

PMID: 36497014 PMC: 9739763. DOI: 10.3390/cells11233753.

The Effect of Schwann Cells/Schwann Cell-Like Cells on Cell Therapy for Peripheral Neuropathy.

Wang Q, Chen F, Ling Z, Su W, Zhao Y, Chen G Front Cell Neurosci. 2022; 16:836931.

PMID: 35350167 PMC: 8957843. DOI: 10.3389/fncel.2022.836931.

Mature but not developing Schwann cells promote axon regeneration after peripheral nerve injury.

Endo T, Kadoya K, Suzuki T, Suzuki Y, Terkawi M, Kawamura D NPJ Regen Med. 2022; 7(1):12.

PMID: 35091563 PMC: 8799715. DOI: 10.1038/s41536-022-00205-y.

Models and methods to study Schwann cells.

Negro S, Pirazzini M, Rigoni M J Anat. 2022; 241(5):1235-1258.

PMID: 34988978 PMC: 9558160. DOI: 10.1111/joa.13606.

hiPSC-Derived Schwann Cells Influence Myogenic Differentiation in Neuromuscular Cocultures.

Horner S, Couturier N, Bruch R, Koch P, Hafner M, Rudolf R Cells. 2021; 10(12).

PMID: 34943800 PMC: 8699767. DOI: 10.3390/cells10123292.

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