Whole-brain Quantitative Mapping of Metabolites Using Short Echo Three-dimensional Proton MRSI

Overview

Journal J Magn Reson Imaging

Date 2014 Nov 29

PMID 25431032

Citations 18

Authors

Angele Lecocq

Yann Le Fur

Andrew A Maudsley

Arnaud Le Troter

Sulaiman Sheriff

Mohamad Sabati

Maxime Donnadieu

Sylviane Confort-Gouny

Patrick J Cozzone

Maxime Guye

Jean-Philippe Ranjeva

Affiliations

Soon will be listed here.

Abstract

Background: To improve the extent over which whole brain quantitative three-dimensional (3D) magnetic resonance spectroscopic imaging (MRSI) maps can be obtained and be used to explore brain metabolism in a population of healthy volunteers.

Methods: Two short echo time (20 ms) acquisitions of 3D echo planar spectroscopic imaging at two orientations, one in the anterior commissure-posterior commissure (AC-PC) plane and the second tilted in the AC-PC +15° plane were obtained at 3 Tesla in a group of 10 healthy volunteers. B1 (+) , B1 (-) , and B0 correction procedures and normalization of metabolite signals with quantitative water proton density measurements were performed. A combination of the two spatially normalized 3D-MRSI, using a weighted mean based on the pixel wise standard deviation metabolic maps of each orientation obtained from the whole group, provided metabolite maps for each subject allowing regional metabolic profiles of all parcels of the automated anatomical labeling (AAL) atlas to be obtained.

Results: The combined metabolite maps derived from the two acquisitions reduced the regional intersubject variance. The numbers of AAL regions showing N-acetyl aspartate (NAA) SD/Mean ratios lower than 30% increased from 17 in the AC-PC orientation and 41 in the AC-PC+15° orientation, to a value of 76 regions of 116 for the combined NAA maps. Quantitatively, regional differences in absolute metabolite concentrations (mM) over the whole brain were depicted such as in the GM of frontal lobes (cNAA = 10.03 + 1.71; cCho = 1.78 ± 0.55; cCr = 7.29 ± 1.69; cmIns = 5.30 ± 2.67) and in cerebellum (cNAA = 5.28 ± 1.77; cCho = 1.60 ± 0.41; cCr = 6.95 ± 2.15; cmIns = 3.60 ± 0.74).

Conclusion: A double-angulation acquisition enables improved metabolic characterization over a wide volume of the brain.

Citing Articles

Exploring in vivo human brain metabolism at 10.5 T: Initial insights from MR spectroscopic imaging.

Hingerl L, Strasser B, Schmidt S, Eckstein K, Genovese G, Auerbach E Neuroimage. 2025; 307:121015.

PMID: 39793640 PMC: 11906155. DOI: 10.1016/j.neuroimage.2025.121015.

Combining sodium MRI, proton MR spectroscopic imaging, and intracerebral EEG in epilepsy.

Azilinon M, Makhalova J, Zaaraoui W, Villalon S, Viout P, Roussel T Hum Brain Mapp. 2022; 44(2):825-840.

PMID: 36217746 PMC: 9842896. DOI: 10.1002/hbm.26102.

Ultrafast B1 mapping with RF-prepared 3D FLASH acquisition: Correcting the bias due to T -induced k-space filtering effect.

Zhu D, Schar M, Qin Q Magn Reson Med. 2022; 88(2):757-769.

PMID: 35381114 PMC: 9232926. DOI: 10.1002/mrm.29247.

Whole-brain high-resolution metabolite mapping with 3D compressed-sensing SENSE low-rank H FID-MRSI.

Klauser A, Klauser P, Grouiller F, Courvoisier S, Lazeyras F NMR Biomed. 2021; 35(1):e4615.

PMID: 34595791 PMC: 9285075. DOI: 10.1002/nbm.4615.

Achieving high-resolution H-MRSI of the human brain with compressed-sensing and low-rank reconstruction at 7 Tesla.

Klauser A, Strasser B, Thapa B, Lazeyras F, Andronesi O J Magn Reson. 2021; 331:107048.

PMID: 34438355 PMC: 8717865. DOI: 10.1016/j.jmr.2021.107048.

References

Michael Tyszka J, Mamelak A . Quantification of B0 homogeneity variation with head pitch by registered three-dimensional field mapping. J Magn Reson. 2002; 159(2):213-8. DOI: 10.1016/s1090-7807(02)00101-5. View

Ebel A, Soher B, Maudsley A . Assessment of 3D proton MR echo-planar spectroscopic imaging using automated spectral analysis. Magn Reson Med. 2001; 46(6):1072-8. DOI: 10.1002/mrm.1301. View

Ebel A, Maudsley A . Improved spectral quality for 3D MR spectroscopic imaging using a high spatial resolution acquisition strategy. Magn Reson Imaging. 2003; 21(2):113-20. DOI: 10.1016/s0730-725x(02)00645-8. View

Christiansen P, Henriksen O, Stubgaard M, Gideon P, Larsson H . In vivo quantification of brain metabolites by 1H-MRS using water as an internal standard. Magn Reson Imaging. 1993; 11(1):107-18. DOI: 10.1016/0730-725x(93)90418-d. View

Barker P, Soher B, Blackband S, Chatham J, Mathews V, Bryan R . Quantitation of proton NMR spectra of the human brain using tissue water as an internal concentration reference. NMR Biomed. 1993; 6(1):89-94. DOI: 10.1002/nbm.1940060114. View

Kreis R, Ernst T, Ross B . Development of the human brain: in vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy. Magn Reson Med. 1993; 30(4):424-37. DOI: 10.1002/mrm.1910300405. View

Posse S, DeCarli C, Le Bihan D . Three-dimensional echo-planar MR spectroscopic imaging at short echo times in the human brain. Radiology. 1994; 192(3):733-8. DOI: 10.1148/radiology.192.3.8058941. View

Charles H, Lazeyras F, Krishnan K, Boyko O, Patterson L, Doraiswamy P . Proton spectroscopy of human brain: effects of age and sex. Prog Neuropsychopharmacol Biol Psychiatry. 1994; 18(6):995-1004. DOI: 10.1016/0278-5846(94)90125-2. View

Barantin L, Le Pape A, Akoka S . A new method for absolute quantitation of MRS metabolites. Magn Reson Med. 1997; 38(2):179-82. DOI: 10.1002/mrm.1910380203. View

10.

Posse S, Olthoff U, Weckesser M, Jancke L, Dager S . Regional dynamic signal changes during controlled hyperventilation assessed with blood oxygen level-dependent functional MR imaging. AJNR Am J Neuroradiol. 1997; 18(9):1763-70. PMC: 8338452. View

11.

Lu H, Nagae-Poetscher L, Golay X, Lin D, Pomper M, van Zijl P . Routine clinical brain MRI sequences for use at 3.0 Tesla. J Magn Reson Imaging. 2005; 22(1):13-22. DOI: 10.1002/jmri.20356. View

12.

Cunningham C, Vigneron D, Chen A, Xu D, Nelson S, Hurd R . Design of flyback echo-planar readout gradients for magnetic resonance spectroscopic imaging. Magn Reson Med. 2005; 54(5):1286-9. DOI: 10.1002/mrm.20663. View

13.

Gasparovic C, Song T, Devier D, Bockholt H, Caprihan A, Mullins P . Use of tissue water as a concentration reference for proton spectroscopic imaging. Magn Reson Med. 2006; 55(6):1219-26. DOI: 10.1002/mrm.20901. View

14.

Maudsley A, Darkazanli A, Alger J, Hall L, Schuff N, Studholme C . Comprehensive processing, display and analysis for in vivo MR spectroscopic imaging. NMR Biomed. 2006; 19(4):492-503. PMC: 2673915. DOI: 10.1002/nbm.1025. View

15.

Yarnykh V . Actual flip-angle imaging in the pulsed steady state: a method for rapid three-dimensional mapping of the transmitted radiofrequency field. Magn Reson Med. 2006; 57(1):192-200. DOI: 10.1002/mrm.21120. View

16.

Tsai S, Posse S, Lin Y, Ko C, Otazo R, Chung H . Fast mapping of the T2 relaxation time of cerebral metabolites using proton echo-planar spectroscopic imaging (PEPSI). Magn Reson Med. 2007; 57(5):859-65. DOI: 10.1002/mrm.21225. View

17.

Otazo R, Tsai S, Lin F, Posse S . Accelerated short-TE 3D proton echo-planar spectroscopic imaging using 2D-SENSE with a 32-channel array coil. Magn Reson Med. 2007; 58(6):1107-16. DOI: 10.1002/mrm.21426. View

18.

NEEB H, Ermer V, Stocker T, Shah N . Fast quantitative mapping of absolute water content with full brain coverage. Neuroimage. 2008; 42(3):1094-109. DOI: 10.1016/j.neuroimage.2008.03.060. View

19.

Gu M, Kim D, Mayer D, Sullivan E, Pfefferbaum A, Spielman D . Reproducibility study of whole-brain 1H spectroscopic imaging with automated quantification. Magn Reson Med. 2008; 60(3):542-7. PMC: 3715396. DOI: 10.1002/mrm.21713. View

20.

Maudsley A, Domenig C, Govind V, Darkazanli A, Studholme C, Arheart K . Mapping of brain metabolite distributions by volumetric proton MR spectroscopic imaging (MRSI). Magn Reson Med. 2008; 61(3):548-59. PMC: 2724718. DOI: 10.1002/mrm.21875. View