» Articles » PMID: 25429733

Ribose-5-phosphate Isomerase A Regulates Hepatocarcinogenesis Via PP2A and ERK Signaling

Overview
Journal Int J Cancer
Specialty Oncology
Date 2014 Nov 29
PMID 25429733
Citations 29
Authors
Affiliations
Soon will be listed here.
Abstract

The deregulated nonoxidative pentose phosphate pathway (PPP) is known to promote oncogenesis, but the molecular mechanism remains unknown. Here, we report that human ribose-5-phosphate isomerase A (RPIA) plays a role in human hepatocellular carcinoma (HCC). A significant increase in RPIA expression was detected both in tumor biopsies of HCC patients and in a liver cancer tissue array. Importantly, the clinicopathological analysis indicated that RPIA mRNA levels were highly correlated with clinical stage, grade, tumor size, types, invasion and alpha-fetoprotein levels in the HCC patients. In addition, we demonstrated that the ability of RPIA to regulate cell proliferation and colony formation in different liver cancer cell lines required ERK signaling as well as the negative modulation of PP2A activity and that the effects of RPIA could be modulated by the addition of either a PP2A inhibitor or activator. Furthermore, the xenograft studies in nude mice revealed that the modulation of RPIA in liver cancer cells regulated tumor growth and that NIH3T3 cells overexpressing RPIA exhibited increased proliferation, enhanced colony formation, elevated levels of p-ERK1/2 and accelerated tumor growth. This study provides new insight into the molecular mechanisms by which RPIA overexpression can induce oncogenesis in HCC. Furthermore, it suggests that RPIA can be a good prognosis biomarker and a potential target for HCC therapy.

Citing Articles

Identification of Energy Metabolism-Related Subtypes and Diagnostic Biomarkers for Osteoarthritis by Integrating Bioinformatics and Machine Learning.

Xu S, Ye J, Cai X J Multidiscip Healthc. 2025; 18:1353-1369.

PMID: 40060994 PMC: 11890432. DOI: 10.2147/JMDH.S510308.


The Pentose Phosphate Pathway: From Mechanisms to Implications for Gastrointestinal Cancers.

Qiao J, Yu Z, Zhou H, Wang W, Wu H, Ye J Int J Mol Sci. 2025; 26(2).

PMID: 39859324 PMC: 11765532. DOI: 10.3390/ijms26020610.


The immune response to RNA suppresses nucleic acid synthesis by limiting ribose 5-phosphate.

Bhattacharjee P, Wang D, Anderson D, Buckler J, de Geus E, Yan F EMBO J. 2024; 43(13):2636-2660.

PMID: 38778156 PMC: 11217295. DOI: 10.1038/s44318-024-00100-w.


A novel proteomic-based model for predicting colorectal cancer with Schistosoma japonicum co-infection by integrated bioinformatics analysis and machine learning.

Li S, Sun X, Li T, Shi Y, Xu B, Deng Y BMC Med Genomics. 2023; 16(1):269.

PMID: 37904220 PMC: 10614356. DOI: 10.1186/s12920-023-01711-8.


Uncovering the Gut-Liver Axis Biomarkers for Predicting Metabolic Burden in Mice.

Yang G, Liu R, Rezaei S, Liu X, Wan Y Nutrients. 2023; 15(15).

PMID: 37571345 PMC: 10421148. DOI: 10.3390/nu15153406.