The Role of the Pentose Phosphate Pathway in Diabetes and Cancer

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2020 Jun 26

PMID 32582032

Citations 146

Authors

Tongxin Ge

Jiawen Yang

Shihui Zhou

Yuchen Wang

Yakui Li

Xuemei Tong

Affiliations

Soon will be listed here.

Abstract

The pentose phosphate pathway (PPP) branches from glucose 6-phosphate (G6P), produces NADPH and ribose 5-phosphate (R5P), and shunts carbons back to the glycolytic or gluconeogenic pathway. The PPP has been demonstrated to be a major regulator for cellular reduction-oxidation (redox) homeostasis and biosynthesis. Enzymes in the PPP are reported to play important roles in many human diseases. In this review, we will discuss the role of the PPP in type 2 diabetes and cancer.

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