Mechano-transduction: from Molecules to Tissues

Overview

Journal PLoS Biol

Specialty Biology

Date 2014 Nov 19

PMID 25405923

Citations 37

Authors

Beth L Pruitt

Alexander R Dunn

William I Weis

W James Nelson

Affiliations

Soon will be listed here.

Abstract

External forces play complex roles in cell organization, fate, and homeostasis. Changes in these forces, or how cells respond to them, can result in abnormal embryonic development and diseases in adults. How cells sense and respond to these mechanical stimuli requires an understanding of the biophysical principles that underlie changes in protein conformation and result in alterations in the organization and function of cells and tissues. Here, we discuss mechano-transduction as it applies to protein conformation, cellular organization, and multi-cell (tissue) function.

Citing Articles

Integrin and Its Associated Proteins as a Mediator for Mechano-Signal Transduction.

Katoh K Biomolecules. 2025; 15(2).

PMID: 40001469 PMC: 11853369. DOI: 10.3390/biom15020166.

Interplay of Glucose Metabolism and Hippo Pathway in Chondrocytes: Pathophysiology and Therapeutic Targets.

Jahn J, Ehlen Q, Kaplan L, Best T, Meng Z, Huang C Bioengineering (Basel). 2024; 11(10).

PMID: 39451348 PMC: 11505586. DOI: 10.3390/bioengineering11100972.

Field Guide to Traction Force Microscopy.

Denisin A, Kim H, Riedel-Kruse I, Pruitt B Cell Mol Bioeng. 2024; 17(2):87-106.

PMID: 38737454 PMC: 11082129. DOI: 10.1007/s12195-024-00801-6.

Activated Human Adipose Tissue Transplantation Promotes Sensorimotor Recovery after Acute Spinal Cord Contusion in Rats.

Bonnet M, Ertlen C, Seblani M, Brezun J, Coyle T, Cereda C Cells. 2024; 13(2).

PMID: 38247873 PMC: 10814727. DOI: 10.3390/cells13020182.

Cell-scaffold interactions in tissue engineering for oral and craniofacial reconstruction.

Wang F, Cai X, Shen Y, Meng L Bioact Mater. 2022; 23:16-44.

PMID: 36406245 PMC: 9650009. DOI: 10.1016/j.bioactmat.2022.10.029.

References

Phan U, Waldron T, Springer T . Remodeling of the lectin-EGF-like domain interface in P- and L-selectin increases adhesiveness and shear resistance under hydrodynamic force. Nat Immunol. 2006; 7(8):883-9. PMC: 1764822. DOI: 10.1038/ni1366. View

Grashoff C, Hoffman B, Brenner M, Zhou R, Parsons M, Yang M . Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature. 2010; 466(7303):263-6. PMC: 2901888. DOI: 10.1038/nature09198. View

Springer T . Structural basis for selectin mechanochemistry. Proc Natl Acad Sci U S A. 2009; 106(1):91-6. PMC: 2629181. DOI: 10.1073/pnas.0810784105. View

Sinha B, Koster D, Ruez R, Gonnord P, Bastiani M, Abankwa D . Cells respond to mechanical stress by rapid disassembly of caveolae. Cell. 2011; 144(3):402-13. PMC: 3042189. DOI: 10.1016/j.cell.2010.12.031. View

Makarenkova H, Hoffman M, Beenken A, Eliseenkova A, Meech R, Tsau C . Differential interactions of FGFs with heparan sulfate control gradient formation and branching morphogenesis. Sci Signal. 2009; 2(88):ra55. PMC: 2884999. DOI: 10.1126/scisignal.2000304. View

Lou J, Yago T, Klopocki A, Mehta P, Chen W, Zarnitsyna V . Flow-enhanced adhesion regulated by a selectin interdomain hinge. J Cell Biol. 2006; 174(7):1107-17. PMC: 2064400. DOI: 10.1083/jcb.200606056. View

Delanoe-Ayari H, Rieu J, Sano M . 4D traction force microscopy reveals asymmetric cortical forces in migrating Dictyostelium cells. Phys Rev Lett. 2011; 105(24):248103. DOI: 10.1103/PhysRevLett.105.248103. View

Galic M, Jeong S, Tsai F, Joubert L, Wu Y, Hahn K . External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane. Nat Cell Biol. 2012; 14(8):874-81. PMC: 3519285. DOI: 10.1038/ncb2533. View

Gjorevski N, Nelson C . Branch formation during organ development. Wiley Interdiscip Rev Syst Biol Med. 2010; 2(6):734-41. PMC: 2951286. DOI: 10.1002/wsbm.96. View

10.

Morita K, Nogawa H . EGF-dependent lobule formation and FGF7-dependent stalk elongation in branching morphogenesis of mouse salivary epithelium in vitro. Dev Dyn. 1999; 215(2):148-54. DOI: 10.1002/(SICI)1097-0177(199906)215:2<148::AID-DVDY7>3.0.CO;2-V. View

11.

del Rio A, Perez-Jimenez R, Liu R, Roca-Cusachs P, Fernandez J, Sheetz M . Stretching single talin rod molecules activates vinculin binding. Science. 2009; 323(5914):638-41. PMC: 9339221. DOI: 10.1126/science.1162912. View

12.

Waldron T, Springer T . Transmission of allostery through the lectin domain in selectin-mediated cell adhesion. Proc Natl Acad Sci U S A. 2009; 106(1):85-90. PMC: 2629216. DOI: 10.1073/pnas.0810620105. View

13.

Klotzsch E, Smith M, Kubow K, Muntwyler S, Little W, Beyeler F . Fibronectin forms the most extensible biological fibers displaying switchable force-exposed cryptic binding sites. Proc Natl Acad Sci U S A. 2009; 106(43):18267-72. PMC: 2761242. DOI: 10.1073/pnas.0907518106. View

14.

Thomas W, Vogel V, Sokurenko E . Biophysics of catch bonds. Annu Rev Biophys. 2008; 37:399-416. DOI: 10.1146/annurev.biophys.37.032807.125804. View

15.

Harunaga J, Hsu J, Yamada K . Dynamics of salivary gland morphogenesis. J Dent Res. 2011; 90(9):1070-7. PMC: 3318079. DOI: 10.1177/0022034511405330. View

16.

Kim H, Ingber D . Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation. Integr Biol (Camb). 2013; 5(9):1130-40. DOI: 10.1039/c3ib40126j. View

17.

Swift J, Ivanovska I, Buxboim A, Harada T, Dingal P, Pinter J . Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation. Science. 2013; 341(6149):1240104. PMC: 3976548. DOI: 10.1126/science.1240104. View

18.

Roberts G, Critchley D . Structural and biophysical properties of the integrin-associated cytoskeletal protein talin. Biophys Rev. 2009; 1(2):61-69. PMC: 2720171. DOI: 10.1007/s12551-009-0009-4. View

19.

Alford P, Feinberg A, Sheehy S, Parker K . Biohybrid thin films for measuring contractility in engineered cardiovascular muscle. Biomaterials. 2010; 31(13):3613-21. PMC: 2838170. DOI: 10.1016/j.biomaterials.2010.01.079. View

20.

Smith M, Gourdon D, Little W, Kubow K, Eguiluz R, Luna-Morris S . Force-induced unfolding of fibronectin in the extracellular matrix of living cells. PLoS Biol. 2007; 5(10):e268. PMC: 1994993. DOI: 10.1371/journal.pbio.0050268. View