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Role of Muscle LIM Protein in Mechanotransduction Process

Overview
Journal Int J Mol Sci
Publisher MDPI
Date 2022 Sep 9
PMID 36077180
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Abstract

The induction of protein synthesis is crucial to counteract the deconditioning of neuromuscular system and its atrophy. In the past, hormones and cytokines acting as growth factors involved in the intracellular events of these processes have been identified, while the implications of signaling pathways associated with the anabolism/catabolism ratio in reference to the molecular mechanism of skeletal muscle hypertrophy have been recently identified. Among them, the mechanotransduction resulting from a mechanical stress applied to the cell appears increasingly interesting as a potential pathway for therapeutic intervention. At present, there is an open question regarding the type of stress to apply in order to induce anabolic events or the type of mechanical strain with respect to the possible mechanosensing and mechanotransduction processes involved in muscle cells protein synthesis. This review is focused on the muscle LIM protein (MLP), a structural and mechanosensing protein with a LIM domain, which is expressed in the sarcomere and costamere of striated muscle cells. It acts as a transcriptional cofactor during cell proliferation after its nuclear translocation during the anabolic process of differentiation and rebuilding. Moreover, we discuss the possible opportunity of stimulating this mechanotransduction process to counteract the muscle atrophy induced by anabolic versus catabolic disorders coming from the environment, aging or myopathies.

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References
1.
Kruger M, Kotter S . Titin, a Central Mediator for Hypertrophic Signaling, Exercise-Induced Mechanosignaling and Skeletal Muscle Remodeling. Front Physiol. 2016; 7:76. PMC: 4771757. DOI: 10.3389/fphys.2016.00076. View

2.
Vernikos J, Schneider V . Space, gravity and the physiology of aging: parallel or convergent disciplines? A mini-review. Gerontology. 2009; 56(2):157-66. DOI: 10.1159/000252852. View

3.
Pardo J, Siliciano J, Craig S . A vinculin-containing cortical lattice in skeletal muscle: transverse lattice elements ("costameres") mark sites of attachment between myofibrils and sarcolemma. Proc Natl Acad Sci U S A. 1983; 80(4):1008-12. PMC: 393517. DOI: 10.1073/pnas.80.4.1008. View

4.
Buckingham M, Rigby P . Gene regulatory networks and transcriptional mechanisms that control myogenesis. Dev Cell. 2014; 28(3):225-38. DOI: 10.1016/j.devcel.2013.12.020. View

5.
Cassandri M, Smirnov A, Novelli F, Pitolli C, Agostini M, Malewicz M . Zinc-finger proteins in health and disease. Cell Death Discov. 2017; 3:17071. PMC: 5683310. DOI: 10.1038/cddiscovery.2017.71. View