Biosynthetic Incorporation of the Azulene Moiety in Proteins with High Efficiency

Overview

Journal Amino Acids

Specialty Biochemistry

Date 2014 Nov 17

PMID 25399056

Citations 8

Authors

Jinfeng Shao

Ivan V Korendovych

Jaap Broos

Affiliations

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Abstract

Biosynthetic incorporation of β-(1-azulenyl)-L-alanine, an isostere of tryptophan, is reported using a tryptophan auxotroph expression host. The azulene moiety introduced this way in proteins features many attractive spectroscopic properties, particularly suitable for in vivo studies.

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