Natural History of Polyomaviruses in Men: the HPV Infection in Men (HIM) Study

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2014 Nov 13

PMID 25387582

Citations 19

Authors

Shalaka S Hampras

Anna R Giuliano

Hui-Yi Lin

Kate J Fisher

Martha E Abrahamsen

Sandrine McKay-Chopin

Tarik Gheit

Massimo Tommasino

Dana E Rollison

Affiliations

Soon will be listed here.

Abstract

Background: Several new polyomaviruses have been discovered in the last decade, including Merkel cell polyomavirus (MCPyV). Little is known about the natural history of the more recently discovered polyomaviruses. We estimated the incidence, prevalence, and persistence of 9 polyomaviruses (MCPyV, BK polyomavirus, KI polyomavirus, JC polyomavirus, WU polyomavirus, Human polyomavirus 6 [HPyV6], HPyV7, HPyV9, and Trichodysplasia spinulosa-associated polyomavirus) and examined factors associated with MCPyV infection in a prospective cohort of 209 men initially enrolled in the HPV Infection in Men (HIM) study.

Methods: Participants enrolled at the US site of the HIM study were recruited into a substudy of cutaneous viral infections and followed for a median of 12.6 months. Eyebrow hair and normal skin swab specimens were obtained at each study visit, and the viral DNA load was measured using multiplex polymerase chain reaction.

Results: MCPyV infection showed the highest prevalence (65.1% of normal skin swab specimens and 30.6% of eyebrow hair specimens), incidence (81.7 cases per 1000 person-months among normal skin swab specimens, and 24.1 cases per 1000 person-months among eyebrow hair specimens), and persistence (85.8% of normal skin swab specimens and 58.9% of eyebrow hair specimens) among all polyomaviruses examined. Age of >44 years (odds ratio [OR], 2.11; 95% confidence interval [CI], 1.03-4.33) and Hispanic race (OR, 2.64; 95% CI, 1.01-6.88) were associated with an increased prevalence of MCPyV infection in eyebrow hair and normal skin swab specimens, respectively.

Conclusion: MCPyV infection is highly prevalent in adults, with age and race being predisposing factors.

Citing Articles

Prevalence and in vitro study of human polyomavirus 9.

Katona M, Jeles K, Takacs P, Csoma E Sci Rep. 2024; 14(1):29313.

PMID: 39592793 PMC: 11599758. DOI: 10.1038/s41598-024-80806-3.

Merkel Cell Polyomavirus: Infection, Genome, Transcripts and Its Role in Development of Merkel Cell Carcinoma.

Houben R, Celikdemir B, Kervarrec T, Schrama D Cancers (Basel). 2023; 15(2).

PMID: 36672392 PMC: 9857234. DOI: 10.3390/cancers15020444.

Prevalence of 13 polyomaviruses in actinic keratosis and matched healthy skin samples of immunocompetent individuals.

Dona M, Gheit T, Chiantore M, Vescio M, Luzi F, Rollo F Infect Agent Cancer. 2022; 17(1):59.

PMID: 36457033 PMC: 9714215. DOI: 10.1186/s13027-022-00472-w.

[Human polyomavirus-associated skin diseases].

Silling S, Kreuter A, Wieland U Hautarzt. 2022; 73(6):426-433.

PMID: 35482045 DOI: 10.1007/s00105-022-04993-8.

Natural History of Incident and Persistent Cutaneous Human Papillomavirus and Human Polyomavirus Infections.

Amorrortu R, Zhao Y, Fenske N, Cherpelis B, Messina J, Giuliano A J Infect Dis. 2022; 226(7):1162-1174.

PMID: 35022780 PMC: 9518839. DOI: 10.1093/infdis/jiac004.

References

Chun S, Yun S, Lee S, Won Y, Lee J . Merkel cell polyomavirus is frequently detected in korean patients with merkel cell carcinoma. Ann Dermatol. 2013; 25(2):203-7. PMC: 3662914. DOI: 10.5021/ad.2013.25.2.203. View

Schmitt M, Bravo I, Snijders P, Gissmann L, Pawlita M, Waterboer T . Bead-based multiplex genotyping of human papillomaviruses. J Clin Microbiol. 2006; 44(2):504-12. PMC: 1392679. DOI: 10.1128/JCM.44.2.504-512.2006. View

Allander T, Andreasson K, Gupta S, Bjerkner A, Bogdanovic G, Persson M . Identification of a third human polyomavirus. J Virol. 2007; 81(8):4130-6. PMC: 1866148. DOI: 10.1128/JVI.00028-07. View

Rockett R, Sloots T, Bowes S, ONeill N, Ye S, Robson J . Detection of novel polyomaviruses, TSPyV, HPyV6, HPyV7, HPyV9 and MWPyV in feces, urine, blood, respiratory swabs and cerebrospinal fluid. PLoS One. 2013; 8(5):e62764. PMC: 3648528. DOI: 10.1371/journal.pone.0062764. View

Lasithiotaki I, Antoniou K, Derdas S, Sarchianaki E, Symvoulakis E, Psaraki A . The presence of Merkel cell polyomavirus is associated with deregulated expression of BRAF and Bcl-2 genes in non-small cell lung cancer. Int J Cancer. 2013; 133(3):604-11. DOI: 10.1002/ijc.28062. View

Robles C, Viscidi R, Malats N, Silverman D, Tardon A, Garcia-Closas R . Bladder cancer and seroreactivity to BK, JC and Merkel cell polyomaviruses: the Spanish bladder cancer study. Int J Cancer. 2013; 133(3):597-603. DOI: 10.1002/ijc.28053. View

Astegiano S, Terlizzi M, Elia M, Cavallo G, Costa C, Cavallo R . Prevalence of polyomaviruses BK, JC, SV40, KI, and WU in non-malignant tonsil specimens. Minerva Med. 2011; 101(6):385-9. View

Cheng J, Rozenblatt-Rosen O, Paulson K, Nghiem P, DeCaprio J . Merkel cell polyomavirus large T antigen has growth-promoting and inhibitory activities. J Virol. 2013; 87(11):6118-26. PMC: 3648111. DOI: 10.1128/JVI.00385-13. View

Rollison D, Giuliano A, Messina J, Fenske N, Cherpelis B, Sondak V . Case-control study of Merkel cell polyomavirus infection and cutaneous squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2011; 21(1):74-81. PMC: 4543303. DOI: 10.1158/1055-9965.EPI-11-0764. View

10.

Sood P, Senanayake S, Sujeet K, Medipalli R, Saad E, Vasudev B . Lower prevalence of BK virus infection in African American renal transplant recipients: a prospective study. Transplantation. 2011; 93(3):291-6. DOI: 10.1097/TP.0b013e31823ec05a. View

11.

Gardner S, Field A, Coleman D, HULME B . New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet. 1971; 1(7712):1253-7. DOI: 10.1016/s0140-6736(71)91776-4. View

12.

Ho J, Jedrych J, Feng H, Natalie A, Grandinetti L, Mirvish E . Human polyomavirus 7-associated pruritic rash and viremia in transplant recipients. J Infect Dis. 2014; 211(10):1560-5. PMC: 4425822. DOI: 10.1093/infdis/jiu524. View

13.

Hattori T, Takeuchi Y, Takenouchi T, Hirofuji A, Tsuchida T, Kabumoto T . The prevalence of Merkel cell polyomavirus in Japanese patients with Merkel cell carcinoma. J Dermatol Sci. 2013; 70(2):99-107. DOI: 10.1016/j.jdermsci.2013.02.010. View

14.

Baez C, Guimaraes M, Martins R, Zalona A, Cossatis J, Zalis M . Detection of Merkel cell polyomavirus in oral samples of renal transplant recipients without Merkel cell carcinoma. J Med Virol. 2013; 85(11):2016-9. DOI: 10.1002/jmv.23687. View

15.

Saiki R, Gelfand D, Stoffel S, Scharf S, Higuchi R, Horn G . Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science. 1988; 239(4839):487-91. DOI: 10.1126/science.2448875. View

16.

Balba G, Javaid B, Timpone Jr J . BK polyomavirus infection in the renal transplant recipient. Infect Dis Clin North Am. 2013; 27(2):271-83. DOI: 10.1016/j.idc.2013.02.002. View

17.

Matsushita M, Kuwamoto S, Iwasaki T, Higaki-Mori H, Yashima S, Kato M . Detection of Merkel cell polyomavirus in the human tissues from 41 Japanese autopsy cases using polymerase chain reaction. Intervirology. 2012; 56(1):1-5. DOI: 10.1159/000338620. View

18.

Anic G, Lee J, Stockwell H, Rollison D, Wu Y, Papenfuss M . Incidence and human papillomavirus (HPV) type distribution of genital warts in a multinational cohort of men: the HPV in men study. J Infect Dis. 2011; 204(12):1886-92. PMC: 3209812. DOI: 10.1093/infdis/jir652. View

19.

van der Meijden E, Janssens R, Lauber C, Bouwes Bavinck J, Gorbalenya A, Feltkamp M . Discovery of a new human polyomavirus associated with trichodysplasia spinulosa in an immunocompromized patient. PLoS Pathog. 2010; 6(7):e1001024. PMC: 2912394. DOI: 10.1371/journal.ppat.1001024. View

20.

Mertz K, Paasinen A, Arnold A, Baumann M, Offner F, Willi N . Merkel cell polyomavirus large T antigen is detected in rare cases of nonmelanoma skin cancer. J Cutan Pathol. 2013; 40(6):543-9. DOI: 10.1111/cup.12129. View