Erythrocytic Mobilization Enhanced by the Granulocyte Colony-stimulating Factor is Associated with Reduced Anthrax-lethal-toxin-induced Mortality in Mice

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Nov 11

PMID 25384016

Citations 8

Authors

Hsin-Hou Chang

Ya-Wen Chiang

Ting-Kai Lin

Guan-Ling Lin

You-Yen Lin

Jyh-Hwa Kau

Hsin-Hsien Huang

Hui-Ling Hsu

Jen-Hung Wang

Der-Shan Sun

Affiliations

Soon will be listed here.

Abstract

Anthrax lethal toxin (LT), one of the primary virulence factors of Bacillus anthracis, causes anthrax-like symptoms and death in animals. Experiments have indicated that levels of erythrocytopenia and hypoxic stress are associated with disease severity after administering LT. In this study, the granulocyte colony-stimulating factor (G-CSF) was used as a therapeutic agent to ameliorate anthrax-LT- and spore-induced mortality in C57BL/6J mice. We demonstrated that G-CSF promoted the mobilization of mature erythrocytes to peripheral blood, resulting in a significantly faster recovery from erythrocytopenia. In addition, combined treatment using G-CSF and erythropoietin tended to ameliorate B. anthracis-spore-elicited mortality in mice. Although specific treatments against LT-mediated pathogenesis remain elusive, these results may be useful in developing feasible strategies to treat anthrax.

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