Current Position of High-resolution MS for Drug Quantification in Clinical & Forensic Toxicology

Overview

Journal Bioanalysis

Specialty Chemistry

Date 2014 Nov 11

PMID 25383737

Citations 5

Authors

Markus R Meyer

Andreas G Helfer

Hans H Maurer

Affiliations

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Abstract

This paper reviews high-resolution MS approaches published from January 2011 until March 2014 for the quantification of drugs (of abuse) and/or their metabolites in biosamples using LC-MS with time-of-flight or Orbitrap™ mass analyzers. Corresponding approaches are discussed including sample preparation and mass spectral settings. The advantages and limitations of high-resolution MS for drug quantification, as well as the demand for a certain resolution or a specific mass accuracy are also explored.

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