Diagnostic Performance of Computed Tomography for Detection of Concomitant Coronary Disease in Hypertrophic Cardiomyopathy

Overview

Journal Eur Radiol

Specialty Radiology

Date 2014 Nov 1

PMID 25358595

Citations 4

Authors

Lei Zhao

Xiaohai Ma

Hailong Ge

Chen Zhang

Zhanhong Wang

Kunihiko Teraoka

Zhanming Fan

Affiliations

Soon will be listed here.

Abstract

Objectives: To evaluate the diagnostic performance of computed tomography (CT) in patients with hypertrophic cardiomyopathy (HCM) and suspected coexistent coronary artery diseases (CADs).

Methods: Sixty patients were enrolled in this study. Cardiac CT examination included CT coronary angiography (CTCA) and delayed enhancement CT. CT performance in evaluation of the coronary artery was assessed and compared with that of catheter-based coronary angiography (CA). The left ventricle (LV) wall thickness, functional indices and myocardial delayed enhancement (MDE) were measured via cardiac magnetic resonance (CMR) and CT images.

Results: Compared with catheter-based CA, CTCA produced a 100 % (24/24) sensitivity, a 94.4 % (34/36) specificity, a 92.3 % (24/26) positive predictive value and a 100 % (34/34) negative predictive value. CT-measured LV wall thickness and functional indices were correlated with those measured via CMR (P < 0.01), though the CT-measured values were smaller than the CMR-measured values. Bland-Altman analysis showed the volume of the focal MDE determined via CT was slightly smaller than that determined using CMR (mean difference: 0.3 cm(3)).

Conclusions: For patients with HCM and suspected coexistent CAD, this comprehensive cardiac CT protocol can be helpful in ruling out coronary stenosis and can provide information regarding morphology, function and tissue characterization of the LV myocardium.

Citing Articles

The Potential Role of Cardiac CT in the Evaluation of Patients With Known or Suspected Cardiomyopathy: From Traditional Indications to Novel Clinical Applications.

Conte E, Mushtaq S, Muscogiuri G, Formenti A, Annoni A, Mancini E Front Cardiovasc Med. 2021; 8:709124.

PMID: 34595219 PMC: 8476802. DOI: 10.3389/fcvm.2021.709124.

Clinical significance of evaluating coronary atherosclerosis in adult patients with hypertrophic cardiomyopathy who have chest pain.

Shin Y, Lee J, Yoo J, Kim J, Jeon Y, Yoon Y Eur Radiol. 2019; 29(9):4593-4602.

PMID: 30796567 DOI: 10.1007/s00330-018-5951-8.

Multimodality Imaging for Left Ventricular Hypertrophy Severity Grading: A Methodological Review.

Alkema M, Spitzer E, Soliman O, Loewe C J Cardiovasc Ultrasound. 2017; 24(4):257-267.

PMID: 28090249 PMC: 5234336. DOI: 10.4250/jcu.2016.24.4.257.

Utility of cardiac CT for evaluating delayed contrast enhancement in dilated cardiomyopathy.

Cerny V, Kuchynka P, Marek J, Lambert L, Masek M, Palecek T Herz. 2016; 42(8):776-780.

PMID: 27981361 DOI: 10.1007/s00059-016-4515-4.

References

Baks T, Cademartiri F, Moelker A, van der Giessen W, Krestin G, Duncker D . Assessment of acute reperfused myocardial infarction with delayed enhancement 64-MDCT. AJR Am J Roentgenol. 2007; 188(2):W135-7. DOI: 10.2214/AJR.05.1176. View

Nieman K, Shapiro M, Ferencik M, Nomura C, Abbara S, Hoffmann U . Reperfused myocardial infarction: contrast-enhanced 64-Section CT in comparison to MR imaging. Radiology. 2008; 247(1):49-56. DOI: 10.1148/radiol.2471070332. View

Lardo A, Cordeiro M, Silva C, Amado L, George R, Saliaris A . Contrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar. Circulation. 2006; 113(3):394-404. PMC: 3410562. DOI: 10.1161/CIRCULATIONAHA.105.521450. View

Cerqueira M, Weissman N, Dilsizian V, Jacobs A, Kaul S, Laskey W . Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation. 2002; 105(4):539-42. DOI: 10.1161/hc0402.102975. View

SCANLON P, Faxon D, Audet A, Carabello B, Dehmer G, Eagle K . ACC/AHA guidelines for coronary angiography. A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (Committee on Coronary Angiography). Developed in collaboration with the Society for Cardiac.... J Am Coll Cardiol. 1999; 33(6):1756-824. DOI: 10.1016/s0735-1097(99)00126-6. View

Kubo T, Kitaoka H, Okawa M, Nishinaga M, Doi Y . Hypertrophic cardiomyopathy in the elderly. Geriatr Gerontol Int. 2010; 10(1):9-16. DOI: 10.1111/j.1447-0594.2009.00572.x. View

Mahnken A, Koos R, Katoh M, Wildberger J, Spuentrup E, Buecker A . Assessment of myocardial viability in reperfused acute myocardial infarction using 16-slice computed tomography in comparison to magnetic resonance imaging. J Am Coll Cardiol. 2005; 45(12):2042-7. DOI: 10.1016/j.jacc.2005.03.035. View

Le Polain De Waroux J, Pouleur A, Goffinet C, Pasquet A, Vanoverschelde J, Gerber B . Combined coronary and late-enhanced multidetector-computed tomography for delineation of the etiology of left ventricular dysfunction: comparison with coronary angiography and contrast-enhanced cardiac magnetic resonance imaging. Eur Heart J. 2008; 29(20):2544-51. PMC: 2567022. DOI: 10.1093/eurheartj/ehn381. View

Maron B, Niimura H, Casey S, Soper M, Wright G, Seidman J . Development of left ventricular hypertrophy in adults in hypertrophic cardiomyopathy caused by cardiac myosin-binding protein C gene mutations. J Am Coll Cardiol. 2001; 38(2):315-21. DOI: 10.1016/s0735-1097(01)01386-9. View

10.

Lima J, Desai M . Cardiovascular magnetic resonance imaging: current and emerging applications. J Am Coll Cardiol. 2004; 44(6):1164-71. DOI: 10.1016/j.jacc.2004.06.033. View

11.

Pennell D, Sechtem U, Higgins C, Manning W, Pohost G, Rademakers F . Clinical indications for cardiovascular magnetic resonance (CMR): Consensus Panel report. Eur Heart J. 2004; 25(21):1940-65. DOI: 10.1016/j.ehj.2004.06.040. View

12.

Balady G, Bricker J, Chaitman B, Fletcher G, Froelicher V, Mark D . ACC/AHA 2002 guideline update for exercise testing: summary article. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1997 Exercise Testing Guidelines). J Am Coll Cardiol. 2002; 40(8):1531-40. DOI: 10.1016/s0735-1097(02)02164-2. View

13.

Naehle C, Kreuz J, Strach K, Schwab J, Pingel S, Luechinger R . Safety, feasibility, and diagnostic value of cardiac magnetic resonance imaging in patients with cardiac pacemakers and implantable cardioverters/defibrillators at 1.5 T. Am Heart J. 2011; 161(6):1096-105. DOI: 10.1016/j.ahj.2011.03.007. View

14.

Okayama S, Soeda T, Kawakami R, Takami Y, Somekawa S, Ueda T . Evaluation of coronary artery disease and cardiac morphology and function in patients with hypertrophic cardiomyopathy, using cardiac computed tomography. Heart Vessels. 2013; 30(1):28-35. DOI: 10.1007/s00380-013-0452-9. View

15.

Berliner J, Kino A, Carr J, Bonow R, Choudhury L . Cardiac computed tomographic imaging to evaluate myocardial scarring/fibrosis in patients with hypertrophic cardiomyopathy: a comparison with cardiac magnetic resonance imaging. Int J Cardiovasc Imaging. 2012; 29(1):191-7. DOI: 10.1007/s10554-012-0048-y. View

16.

Moon J, McKenna W, McCrohon J, Elliott P, Smith G, Pennell D . Toward clinical risk assessment in hypertrophic cardiomyopathy with gadolinium cardiovascular magnetic resonance. J Am Coll Cardiol. 2003; 41(9):1561-7. DOI: 10.1016/s0735-1097(03)00189-x. View

17.

Maron M, Maron B, Harrigan C, Buros J, Gibson C, Olivotto I . Hypertrophic cardiomyopathy phenotype revisited after 50 years with cardiovascular magnetic resonance. J Am Coll Cardiol. 2009; 54(3):220-8. DOI: 10.1016/j.jacc.2009.05.006. View

18.

Maron M, Olivotto I, Maron B, Prasad S, Cecchi F, Udelson J . The case for myocardial ischemia in hypertrophic cardiomyopathy. J Am Coll Cardiol. 2009; 54(9):866-75. DOI: 10.1016/j.jacc.2009.04.072. View

19.

Meijboom W, van Mieghem C, Mollet N, Pugliese F, Weustink A, Van Pelt N . 64-slice computed tomography coronary angiography in patients with high, intermediate, or low pretest probability of significant coronary artery disease. J Am Coll Cardiol. 2007; 50(15):1469-75. DOI: 10.1016/j.jacc.2007.07.007. View

20.

Gersh B, Maron B, Bonow R, Dearani J, Fifer M, Link M . 2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Developed in collaboration with the.... J Am Coll Cardiol. 2011; 58(25):e212-60. DOI: 10.1016/j.jacc.2011.06.011. View