Evaluation of Coronary Artery Disease and Cardiac Morphology and Function in Patients with Hypertrophic Cardiomyopathy, Using Cardiac Computed Tomography

Overview

Journal Heart Vessels

Specialty Cardiology & Vascular Diseases

Date 2013 Dec 12

PMID 24326884

Citations 9

Authors

Satoshi Okayama

Tsunenari Soeda

Rika Kawakami

Yasuhiro Takami

Satoshi Somekawa

Tomoya Ueda

Yu Sugawara

Takaki Matsumoto

Ji Hee Sung

Taku Nishida

Shiro Uemura

Yoshihiko Saito

Affiliations

Soon will be listed here.

Abstract

Coronary artery disease and cardiac morphology and function were evaluated in 51 patients with hypertrophic cardiomyopathy (HCM), without typical chest pain, using cardiac computed tomography (CT). This study investigated the prevalence of coronary artery disease, the indicators of obstructive coronary stenosis, and the magnitude of left ventricular (LV) hypertrophy. The patients' mean coronary artery calcium score was 198.8 ± 312.0 and was positively correlated with the number of coronary risk factors (r = 0.32; P < 0.05). Of the 51 patients with HCM, 42 (82.4 %) had some degree of stenosis and 8 (15.7 %) had obstructive stenosis. Noncalcified and mixed plaques were detected in 14 (27.5 %) and 11 (21.6 %) patients, respectively. Multivariate logistic regression revealed that diabetes was an independent indicator of the presence of obstructive stenosis in HCM patients. Multivariate linear regression revealed that low estimated glomerular filtration rates and high triglyceride concentrations were independent indicators of higher LV mass indexes. In conclusion, cardiac CT revealed that coronary artery disease was common among patients with HCM. The presence of obstructive coronary stenosis and the magnitude of LV hypertrophy were related to the presence of diabetes, triglyceride levels, and estimated glomerular filtration rate.

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