A French Multicentric Study and Review of Pulmonary Nocardia Spp. in Cystic Fibrosis Patients

Overview

Journal Med Microbiol Immunol

Specialty Allergy & Immunology

Date 2014 Oct 27

PMID 25344657

Citations 11

Authors

Veronica Rodriguez-Nava

Stephane Durupt

Sandra Chyderiotis

Anne-Marie Freydiere

Judith Karsenty

Michele de Montclos

Philippe Reix

Isabelle Durieu

Raphaele Nove-Josserand

Raphael Chiron

Francois Bremont

Laurent Tetu

Marlene Murris

Dominique Terru

Sylvain Godreuil

Emmanuelle Bergeron

Jean Freney

Patrick Boiron

Francois Vandenesch

Helene Marchandin

Christine Segonds

Anne Doleans-Jordheim

Affiliations

Soon will be listed here.

Abstract

Some bacterial species recovered from the airways of cystic fibrosis (CF) patients are indisputably associated with lung infections, whereas the clinical relevance of others, such as Nocardia spp., remains unclear. Sixteen French CF cases of colonization/infection with Nocardia spp. were reviewed in order to evaluate the epidemiology, the clinical impact and the potential treatment of these bacteria, and results were compared to those of the literature. Five Nocardia species were identified, Nocardia cyriacigeorgica being the major species (50 % of cases). At first isolation, Nocardia was the sole pathogen recovered in six patients. Seven patients presented pulmonary exacerbation. For 12 patients, antimicrobial treatment against Nocardia was started immediately, mainly based on cotrimoxazole (6 of the 12 cases). In this study, we highlight the heterogeneity of the clinical management of Nocardia spp. in CF. Guidelines for the clinical management of Nocardia infections in CF patients are proposed.

Citing Articles

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