Known Unknowns for Allele-specific Expression and Genomic Imprinting Effects

Overview

Journal F1000Prime Rep

Specialty Biomedical Engineering

Date 2014 Oct 25

PMID 25343032

Citations 7

Authors

Christopher Gregg

Affiliations

Soon will be listed here.

Abstract

Recent studies have provided evidence for non-canonical imprinting effects that are associated with allele-specific expression biases at the tissue level in mice. These imprinting effects have features that are distinct from canonical imprinting effects that involve allele silencing. Here, I discuss some of the evidence for non-canonical imprinting effects in the context of random X-inactivation and epigenetic allele-specific expression effects on the autosomes. I propose several mechanisms that may underlie non-canonical imprinting effects and outline future directions and approaches to study these effects at the cellular level in vivo. The growing evidence for complex allele-specific expression effects that are cell- and developmental stage-specific has opened a new frontier for study. Currently, the function of these effects and the underlying regulatory mechanisms are largely unknown.

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