Evolution of B Cell Immunity

Overview

Journal Annu Rev Anim Biosci

Publisher Annual Reviews

Specialties Biology
Genetics
Veterinary Medicine

Date 2014 Oct 24

PMID 25340015

Citations 45

Authors

David Parra

Fumio Takizawa

J Oriol Sunyer

Affiliations

Soon will be listed here.

Abstract

Two types of adaptive immune strategies are known to have evolved in vertebrates: the VLR-based system, which is present in jawless organisms and is mediated by VLRA and VLRB lymphocytes, and the BCR/TCR-based system, which is present in jawed species and is provided by B and T cell receptors expressed on B and T cells, respectively. Here we summarize features of B cells and their predecessors in the different animal phyla, focusing the review on B cells from jawed vertebrates. We point out the critical role of nonclassical species and comparative immunology studies in the understanding of B cell immunity. Because nonclassical models include species relevant to veterinary medicine, basic science research performed in these animals contributes to the knowledge required for the development of more efficacious vaccines against emerging pathogens.

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