Endoplasmic Reticulum Stress and Cancer

Overview

Journal J Cancer Prev

Specialty Oncology

Date 2014 Oct 23

PMID 25337575

Citations 177

Authors

Raj Kumar Yadav

Soo-Wan Chae

Hyung-Ryong Kim

Han Jung Chae

Affiliations

Soon will be listed here.

Abstract

The endoplasmic reticulum (ER) is the principal organelle responsible for multiple cellular functions including protein folding and maturation and the maintenance of cellular homeostasis. ER stress is activated by a variety of factors and triggers the unfolded protein response (UPR), which restores homeostasis or activates cell death. Multiple studies have clarified the link between ER stress and cancer, and particularly the involvement of the UPR. The UPR seems to adjust the paradoxical microenvironment of cancer and, as such, is one of resistance mechanisms against cancer therapy. This review describes the activity of different UPRs involved in tumorigenesis and resistance to cancer therapy.

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