Association Between Angiotensin I-converting Enzyme Gene Polymorphism and Susceptibility to Cancer: a Meta Analysis

Overview

Journal Int J Clin Exp Pathol

Specialty Pathology

Date 2014 Oct 23

PMID 25337282

Citations 7

Authors

Kan Zhang

Dan Cheng

Lingling Yi

Huimin Shi

Guohua Zhen

Affiliations

Soon will be listed here.

Abstract

Background: Angiotensin I-converting enzyme (ACE) gene plays an important role in the pathogenesis of cancers. The association between ACE insertion/deletion (I/D) polymorphism and the risk of various cancers has been studied. However, the results of these studies remain conflicting. Therefore, we performed a meta-analysis to evaluate the association between ACE I/D polymorphism and the risk of cancers.

Methods: PubMed, Embase, ScienceDirect, Springer, CNKI, Wanfang, Weipu, CBM databases and Google Scholar were searched for case-control studies on ACE I/D polymorphism and the risk of cancers, published up to Dec 31, 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association between ACE I/D polymorphism and cancer risk.

Results: Thirty-five published studies with 5007 cases and 8173 controls were included. Overall, there were no significant association between ACE I/D polymorphism and the risk of cancers (II vs. ID+DD OR = 1.05, 95% CI = 0.89-1.23, I vs. D OR = 1.00, 95% CI = 0.89-1.13). However, when stratified by ethnicity, we found a significant association between this polymorphism and cancer risk in Caucasians (II vs. ID+DD: OR = 1.43, 95% CI = 1.02-2.00, I vs. D: OR = 1.23, 95% CI 1.01-1.49).

Conclusion: ACE I/D polymorphism is associated with the cancer risk in Caucasians.

Citing Articles

Contribution of Endothelial Dysfunction to Cancer Susceptibility and Progression: A Comprehensive Narrative Review on the Genetic Risk Component.

de Melo I, Tavares V, Pereira D, Medeiros R Curr Issues Mol Biol. 2024; 46(5):4845-4873.

PMID: 38785560 PMC: 11120512. DOI: 10.3390/cimb46050292.

Association of a common genetic variant (insertion/deletion) in ACE gene with prostate cancer susceptibility in a Tunisian population.

Said R, Jenni R, Boussetta S, Ammous F, Zouari S, Zaghbib S J Clin Lab Anal. 2021; 36(1):e24129.

PMID: 34799866 PMC: 8761439. DOI: 10.1002/jcla.24129.

Alterations in Gene Expression of Renin-Angiotensin System Components and Related Proteins in Colorectal Cancer.

Mehranfard D, Perez G, Rodriguez A, Ladna J, Neagra C, Goldstein B J Renin Angiotensin Aldosterone Syst. 2021; 2021:9987115.

PMID: 34285715 PMC: 8277508. DOI: 10.1155/2021/9987115.

Association of Angiotensin I Converting Enzyme Insertion/287 bp Deletion Polymorphisms and Proliferative Prostatic Diseases among Lebanese Men.

El Ezzi A, Clawson J, El-Saidi M, Zaidan W, Kovash A, Orellana J Prostate Cancer. 2020; 2020:5959134.

PMID: 32089890 PMC: 7029258. DOI: 10.1155/2020/5959134.

Association of Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism with Recurrent Pregnancy Loss: a Meta-Analysis of 26 Case-Control Studies.

Aslbahar F, Neamatzadeh H, Tabatabaiee R, Karimi-Zarchi M, Javaheri A, Mazaheri M Rev Bras Ginecol Obstet. 2018; 40(10):631-641.

PMID: 30352462 PMC: 10316902. DOI: 10.1055/s-0038-1672137.

References

Lukic S, Nikolic A, Alempijevic T, Popovic D, Sokic Milutinovic A, Ugljesic M . Angiotensin-converting enzyme gene insertion/deletion polymorphism in patients with chronic pancreatitis and pancreatic cancer. Dig Surg. 2011; 28(4):258-62. DOI: 10.1159/000328666. View

Medeiros R, Vasconcelos A, Costa S, Pinto D, Lobo F, Morais A . Linkage of angiotensin I-converting enzyme gene insertion/deletion polymorphism to the progression of human prostate cancer. J Pathol. 2004; 202(3):330-5. DOI: 10.1002/path.1529. View

Goto Y, Ando T, Nishio K, Ishida Y, Kawai S, Goto H . The ACE gene polymorphism is associated with the incidence of gastric cancer among H. pylori seropositive subjects with atrophic gastritis. Asian Pac J Cancer Prev. 2006; 6(4):464-7. View

Laird N, Ware J . Random-effects models for longitudinal data. Biometrics. 1982; 38(4):963-74. View

Yigit B, Bozkurt N, Narter F, Yilmaz H, Yucebas E, Isbir T . Effects of ACE I/D polymorphism on prostate cancer risk, tumor grade and metastatis. Anticancer Res. 2007; 27(2):933-6. View

Wu J, Akaike T, Hayashida K, Miyamoto Y, Nakagawa T, Miyakawa K . Identification of bradykinin receptors in clinical cancer specimens and murine tumor tissues. Int J Cancer. 2002; 98(1):29-35. DOI: 10.1002/ijc.10142. View

Abali H, Gullu I, Engin H, Haznedaroglu I, Erman M, Tekuzman G . Old antihypertensives as novel antineoplastics: angiotensin-I-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists. Med Hypotheses. 2002; 59(3):344-8. DOI: 10.1016/s0306-9877(02)00185-8. View

Sugimoto M, Furuta T, Shirai N, Ikuma M, Sugimura H, Hishida A . Influences of chymase and angiotensin I-converting enzyme gene polymorphisms on gastric cancer risks in Japan. Cancer Epidemiol Biomarkers Prev. 2006; 15(10):1929-34. DOI: 10.1158/1055-9965.EPI-06-0339. View

Deshayes F, Nahmias C . Angiotensin receptors: a new role in cancer?. Trends Endocrinol Metab. 2005; 16(7):293-9. DOI: 10.1016/j.tem.2005.07.009. View

10.

Yuan F, Zhang L, Li H, Liao M, Lv M, Zhang C . Influence of angiotensin I-converting enzyme gene polymorphism on hepatocellular carcinoma risk in China. DNA Cell Biol. 2013; 32(5):268-73. PMC: 3651688. DOI: 10.1089/dna.2012.1910. View

11.

Haiman C, Henderson S, Bretsky P, Kolonel L, Henderson B . Genetic variation in angiotensin I-converting enzyme (ACE) and breast cancer risk: the multiethnic cohort. Cancer Res. 2003; 63(20):6984-7. View

12.

Cheon K, Choi K, Lee H, Park S, Rhee Y, Lee Y . Gene polymorphisms of endothelial nitric oxide synthase and angiotensin-converting enzyme in patients with lung cancer. Lung. 2001; 178(6):351-60. DOI: 10.1007/s004080000039. View

13.

Egami K, Murohara T, Shimada T, Sasaki K, Shintani S, Sugaya T . Role of host angiotensin II type 1 receptor in tumor angiogenesis and growth. J Clin Invest. 2003; 112(1):67-75. PMC: 162282. DOI: 10.1172/JCI16645. View

14.

Tunny T, Xu L, Richardson K, Stowasser M, Gartside M, Gordon R . Insertion/deletion polymorphism of the angiotensin-converting enzyme gene and loss of the insertion allele in aldosterone-producing adenoma. J Hum Hypertens. 1996; 10(12):827-30. View

15.

Zhang Y, Huang J, Zhang J, Li X, He C, Xiao Y . RANTES gene polymorphisms and asthma risk: A meta-analysis. Arch Med Res. 2010; 41(1):50-8. DOI: 10.1016/j.arcmed.2010.01.002. View

16.

Fujita M, Hayashi I, Yamashina S, Fukamizu A, Itoman M, Majima M . Angiotensin type 1a receptor signaling-dependent induction of vascular endothelial growth factor in stroma is relevant to tumor-associated angiogenesis and tumor growth. Carcinogenesis. 2005; 26(2):271-9. DOI: 10.1093/carcin/bgh324. View

17.

Carl-McGrath S, Lendeckel U, Ebert M, Wolter A, Roessner A, Rocken C . The ectopeptidases CD10, CD13, CD26, and CD143 are upregulated in gastric cancer. Int J Oncol. 2004; 25(5):1223-32. View

18.

Nacak M, Nacak I, Sanli M, Ozkur M, Pektas M, Sukru Aynacioglu A . Association of angiotensin converting enzyme gene insertion/deletion polymorphism with lung cancer in Turkey. Cancer Genet Cytogenet. 2010; 198(1):22-6. DOI: 10.1016/j.cancergencyto.2009.11.019. View

19.

Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F . An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990; 86(4):1343-6. PMC: 296868. DOI: 10.1172/JCI114844. View

20.

Kaufman K, Kelly J, Gray-McGuire C, Asundi N, Yu H, Reid J . Linkage analysis of angiotensin-converting enzyme (ACE) insertion/deletion polymorphism and systemic lupus erythematosus. Mol Cell Endocrinol. 2001; 177(1-2):81-5. DOI: 10.1016/s0303-7207(01)00424-5. View