Photodynamic Therapy for Esophageal Cancer

Overview

Journal Ann Transl Med

Publisher AME Publishing Company

Date 2014 Oct 22

PMID 25333005

Citations 33

Authors

Tomonori Yano

Ken Hatogai

Hiroyuki Morimoto

Yusuke Yoda

Kazuhiro Kaneko

Affiliations

Soon will be listed here.

Abstract

Photodynamic therapy (PDT) is a treatment that uses a photosensitizing drug that is administered to the patient, localized to a tumor, and then activated with a laser to induce a photochemical reaction to destroy the cell. PDT using porfimer sodium followed by excimer dye laser irradiation is approved as a curative treatment for superficial esophageal cancer in Japan. While endoscopic submucosal dissection (ESD) is currently more popular for esophageal cancer, there is evidence to support PDT as an alternative treatment and as a salvage treatment for local failure after chemoradiotherapy (CRT). A photosensitizing agent has also been developed that requires a shorter sun shade period after administration, and studies are currently underway to establish an esophageal cancer indication for this next-generation PDT in Japan.

Citing Articles

Recent Progress in Photothermal, Photodynamic and Sonodynamic Cancer Therapy: Through the cGAS-STING Pathway to Efficacy-Enhancing Strategies.

Fang K, Zhang H, Kong Q, Ma Y, Xiong T, Qin T Molecules. 2024; 29(15).

PMID: 39125107 PMC: 11314065. DOI: 10.3390/molecules29153704.

The use of photodynamic therapy in medical practice.

Aebisher D, Rogoz K, Mysliwiec A, Dynarowicz K, Wiench R, Cieslar G Front Oncol. 2024; 14:1373263.

PMID: 38803535 PMC: 11129581. DOI: 10.3389/fonc.2024.1373263.

Photodynamic Therapy and Immunological View in Gastrointestinal Tumors.

Aebisher D, Woznicki P, Dynarowicz K, Kawczyk-Krupka A, Cieslar G, Bartusik-Aebisher D Cancers (Basel). 2024; 16(1).

PMID: 38201494 PMC: 10777986. DOI: 10.3390/cancers16010066.

Unveiling Therapeutic Targets for Esophageal Cancer: A Comprehensive Review.

Acharya R, Mahapatra A, Verma H, Bhaskar L Curr Oncol. 2023; 30(11):9542-9568.

PMID: 37999111 PMC: 10670555. DOI: 10.3390/curroncol30110691.

Polymer theranostics with multiple stimuli-based activation of photodynamic therapy and tumor imaging.

Tavares M, Islam R, Subr V, Hackbarth S, Gao S, Yang K Theranostics. 2023; 13(14):4952-4973.

PMID: 37771769 PMC: 10526675. DOI: 10.7150/thno.86211.

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