Potent Selective Inhibitors of Protein Kinase C

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 1989 Dec 18

PMID 2532156

Citations 114

Authors

P D Davis

C H Hill

E Keech

G Lawton

J S Nixon

A D Sedgwick

J Wadsworth

D Westmacott

S E Wilkinson

Affiliations

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Abstract

A series of potent, selective inhibitors of protein kinase C has been derived from the structural lead provided by the microbial broth products, staurosporine and K252a. Our inhibitors block PCK in intact cells (platelets and T cells), and prevent the proliferation of mononuclear cells in response to interleukin 2 (IL2).

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