Significance of MTA1 in the Molecular Characterization of Osteosarcoma
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Osteosarcoma is the most common malignant bone tumor in children and characterized by aggressive biologic behavior of metastatic propensity to the lung. Change of treatment paradigm brings survival benefit; however, 5-year survival rate is still low in patients having metastastatic foci at diagnosis for a few decades. Metastasis-associated protein (MTA) family is a group of ubiquitously expressed coregulators, which influences on tumor invasiveness or metastasis. MTA1 has been investigated in various cancers including osteosarcoma, and its overexpression is associated with high-risk features of cancers. In this review, we described various molecular studies of osteosarcoma, especially associated with MTA1.
Zhang L, Song J, Xu X, Sun D, Huang H, Chen Y Int J Exp Pathol. 2025; 106(2):e12524.
PMID: 39891384 PMC: 11785588. DOI: 10.1111/iep.12524.
miR-30 inhibits the progression of osteosarcoma by targeting MTA1.
Zhao A, Zhao Y, Feng W, Zhao Z, Liu W, Wang N J Musculoskelet Neuronal Interact. 2022; 22(2):261-268.
PMID: 35642705 PMC: 9186454.
M6A RNA Methylation Regulates Histone Ubiquitination to Support Cancer Growth and Progression.
Yadav P, Subbarayalu P, Medina D, Nirzhor S, Timilsina S, Rajamanickam S Cancer Res. 2022; 82(10):1872-1889.
PMID: 35303054 PMC: 9336196. DOI: 10.1158/0008-5472.CAN-21-2106.
Prognostic and clinicopathological significance of circulating tumor cells in osteosarcoma.
Li M, Lu Y, Long Z, Li M, Kong J, Chen G J Bone Oncol. 2019; 16:100236.
PMID: 31024791 PMC: 6475710. DOI: 10.1016/j.jbo.2019.100236.
Sun X, Xu Y, Zhang S, Li X, Wang Y, Zhang Y Exp Ther Med. 2018; 15(6):5058-5064.
PMID: 29805531 PMC: 5958772. DOI: 10.3892/etm.2018.6068.