Chronic Stress Impairs Collateral Blood Flow Recovery in Aged Mice

Overview

Journal J Cardiovasc Transl Res

Publisher Springer

Specialty Cardiology & Vascular Diseases

Date 2014 Oct 16

PMID 25315467

Citations 4

Authors

Roberta M Lassance-Soares

Subeena Sood

Nabarun Chakraborty

Sunny Jhamnani

Nima Aghili

Hajra Nashin

Rasha Hammamieh

Marti Jett

Stephen E Epstein

Mary Susan Burnett

Affiliations

Soon will be listed here.

Abstract

Chronic stress is associated with increased risk of cardiovascular diseases. Aging is also associated with vascular dysfunction. We hypothesize that chronic stress accelerates collateral dysfunction in old mice. Mice were subjected to either chronic social defeat (CSD) or chronic cold stress (CCS). The CSD mice were housed in a box inside an aggressor's cage and exposed to the aggressor. The CCS group was placed in iced water. After chronic stress, mice underwent femoral artery ligation (FAL) and flow recovery was measured. For the CSD group, appearance and use scores of the foot and a behavioral test were performed. CSD impaired collateral flow recovery after FAL. Further, stressed mice had greater ischemic damage, impaired foot function, and altered behavior. The CCS mice also showed impaired collateral flow recovery. Chronic stress causes hind limb collateral dysfunction in old mice, a conclusion reinforced by the fact that two types of stress produced similar changes.

Citing Articles

Innate sensitivity to stress facilitates inflammation, alters metabolism and shortens lifespan in a mouse model of social hierarchy.

Bairachnaya M, Agranyoni O, Antoch M, Michaelevski I, Pinhasov A Aging (Albany NY). 2019; 11(21):9901-9911.

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Brain-Immune Alterations and Mitochondrial Dysfunctions in a Mouse Model of Paediatric Autoimmune Disorder Associated with Streptococcus: Exacerbation by Chronic Psychosocial Stress.

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Social stress shortens lifespan in mice.

Razzoli M, Nyuyki-Dufe K, Gurney A, Erickson C, McCallum J, Spielman N Aging Cell. 2018; 17(4):e12778.

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Preclinical evaluation of mesenchymal stem cells overexpressing VEGF to treat critical limb ischemia.

Beegle J, Magner N, Kalomoiris S, Harding A, Zhou P, Nacey C Mol Ther Methods Clin Dev. 2016; 3:16053.

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