Alcohol and the Sleeping Brain

Overview

Journal Handb Clin Neurol

Publisher Elsevier

Specialty Neurology

Date 2014 Oct 14

PMID 25307588

Citations 62

Authors

Ian M Colrain

Christian L Nicholas

Fiona C Baker

Affiliations

Soon will be listed here.

Abstract

Alcohol acts as a sedative that interacts with several neurotransmitter systems important in the regulation of sleep. Acute administration of large amounts of alcohol prior to sleep leads to decreased sleep-onset latency and changes in sleep architecture early in the night, when blood alcohol levels are high, with subsequent disrupted, poor-quality sleep later in the night. Alcohol abuse and dependence are associated with chronic sleep disturbance, lower slow-wave sleep, and more rapid-eye-movement sleep than normal, that last long into periods of abstinence and may play a role in relapse. This chapter outlines the evidence for acute and chronic alcohol effects on sleep architecture and sleep electroencephalogram, evidence for tolerance with repeated administration, and possible underlying neurochemical mechanisms for alcohol's effects on sleep. Also discussed are sex differences as well as effects of alcohol on sleep homeostasis and circadian regulation. Evidence for the role of sleep disruption as a risk factor for developing alcohol dependence is discussed in the context of research conducted in adolescents. The utility of sleep-evoked potentials in the assessment of the effects of alcoholism on sleep and the brain and in abstinence-mediated recovery is also outlined. The chapter concludes with a series of questions that need to be answered to determine the role of sleep and sleep disturbance in the development and maintenance of problem drinking and the potential beneficial effects of the treatment of sleep disorders for maintenance of abstinence in alcoholism.

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References

Pieters S, Van der Vorst H, Burk W, Wiers R, Engels R . Puberty-dependent sleep regulation and alcohol use in early adolescents. Alcohol Clin Exp Res. 2010; 34(9):1512-8. DOI: 10.1111/j.1530-0277.2010.01235.x. View

Cardenas V, Studholme C, Gazdzinski S, Durazzo T, Meyerhoff D . Deformation-based morphometry of brain changes in alcohol dependence and abstinence. Neuroimage. 2006; 34(3):879-87. PMC: 1865510. DOI: 10.1016/j.neuroimage.2006.10.015. View

Pfefferbaum A, Mathalon D, Sullivan E, Rawles J, Zipursky R, Lim K . A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Arch Neurol. 1994; 51(9):874-87. DOI: 10.1001/archneur.1994.00540210046012. View

McCarley R . Neurobiology of REM sleep. Handb Clin Neurol. 2010; 98:151-71. DOI: 10.1016/B978-0-444-52006-7.00010-1. View

Sano H, Suzuki Y, Yazaki R, Tamefusa K, Yokoyama T, Miyasato K . Circadian variation in plasma 5-hydroxyindoleacetic acid level during and after alcohol withdrawal: phase advances in alcoholic patients compared with normal subjects. Acta Psychiatr Scand. 1993; 87(4):291-6. DOI: 10.1111/j.1600-0447.1993.tb03374.x. View

Kelm M, Criswell H, Breese G . Ethanol-enhanced GABA release: a focus on G protein-coupled receptors. Brain Res Rev. 2010; 65(2):113-23. PMC: 3005894. DOI: 10.1016/j.brainresrev.2010.09.003. View

Roberts R, Roberts C, Duong H . Chronic insomnia and its negative consequences for health and functioning of adolescents: a 12-month prospective study. J Adolesc Health. 2008; 42(3):294-302. PMC: 2488408. DOI: 10.1016/j.jadohealth.2007.09.016. View

Harper C, Kril J, Daly J . Are we drinking our neurones away?. Br Med J (Clin Res Ed). 1987; 294(6571):534-6. PMC: 1245575. DOI: 10.1136/bmj.294.6571.534. View

Carden W, Alexander G, Friedman D, Daunais J, Grant K, Mu J . Chronic ethanol drinking reduces native T-type calcium current in the thalamus of nonhuman primates. Brain Res. 2006; 1089(1):92-100. DOI: 10.1016/j.brainres.2006.02.135. View

10.

Thompson P, Gillin J, Golshan S, Irwin M . Polygraphic sleep measures differentiate alcoholics and stimulant abusers during short-term abstinence. Biol Psychiatry. 1995; 38(12):831-6. DOI: 10.1016/0006-3223(95)00070-4. View

11.

Zahr N, Pitel A, Chanraud S, Sullivan E . Contributions of studies on alcohol use disorders to understanding cerebellar function. Neuropsychol Rev. 2010; 20(3):280-9. PMC: 2998898. DOI: 10.1007/s11065-010-9141-y. View

12.

Evans S, Levin F . Response to alcohol in women: role of the menstrual cycle and a family history of alcoholism. Drug Alcohol Depend. 2010; 114(1):18-30. PMC: 3017640. DOI: 10.1016/j.drugalcdep.2010.09.001. View

13.

Porjesz B, Almasy L, Edenberg H, Wang K, Chorlian D, Foroud T . Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locus. Proc Natl Acad Sci U S A. 2002; 99(6):3729-33. PMC: 122592. DOI: 10.1073/pnas.052716399. View

14.

Kodama H, Nakazawa Y, Kotorii T, Nonaka K, INANAGA K, Ohshima M . Biorhythm of core temperature in depressive and non-depressive alcoholics. Drug Alcohol Depend. 1988; 21(1):1-6. DOI: 10.1016/0376-8716(88)90002-6. View

15.

Rangaswamy M, Porjesz B . Understanding alcohol use disorders with neuroelectrophysiology. Handb Clin Neurol. 2014; 125:383-414. PMC: 4331067. DOI: 10.1016/B978-0-444-62619-6.00023-9. View

16.

Mukai M, Uchimura N, Hirano T, Ohshima H, Ohshima M, Nakamura J . Circadian rhythms of hormone concentrations in alcohol withdrawal. Psychiatry Clin Neurosci. 1998; 52(2):238-40. DOI: 10.1111/j.1440-1819.1998.tb01051.x. View

17.

Roberts R, Roberts C, Duong H . Sleepless in adolescence: prospective data on sleep deprivation, health and functioning. J Adolesc. 2009; 32(5):1045-57. PMC: 2735816. DOI: 10.1016/j.adolescence.2009.03.007. View

18.

Borbely A . A two process model of sleep regulation. Hum Neurobiol. 1982; 1(3):195-204. View

19.

Feige B, Scaal S, Hornyak M, Gann H, Riemann D . Sleep electroencephalographic spectral power after withdrawal from alcohol in alcohol-dependent patients. Alcohol Clin Exp Res. 2007; 31(1):19-27. DOI: 10.1111/j.1530-0277.2006.00260.x. View

20.

Finelli L, Borbely A, Achermann P . Functional topography of the human nonREM sleep electroencephalogram. Eur J Neurosci. 2001; 13(12):2282-90. DOI: 10.1046/j.0953-816x.2001.01597.x. View