Linkage Disequilibrium Between the Beta Frequency of the Human EEG and a GABAA Receptor Gene Locus

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2002 Mar 14

PMID 11891318

Citations 124

Authors

Bernice Porjesz

Laura Almasy

Howard J Edenberg

Kongming Wang

David B Chorlian

Tatiana Foroud

Alison Goate

John P Rice

Sean J OConnor

John Rohrbaugh

Samuel Kuperman

Lance O Bauer

Raymond R Crowe

Marc A Schuckit

Victor Hesselbrock

P Michael Conneally

Jay A Tischfield

Ting-Kai Li

Theodore Reich

Henri Begleiter

Affiliations

Soon will be listed here.

Abstract

Human brain oscillations represent important features of information processing and are highly heritable. A common feature of beta oscillations (13-28 Hz) is the critical involvement of networks of inhibitory interneurons as pacemakers, gated by gamma-aminobutyric acid type A (GABA(A)) action. Advances in molecular and statistical genetics permit examination of quantitative traits such as the beta frequency of the human electroencephalogram in conjunction with DNA markers. We report a significant linkage and linkage disequilibrium between beta frequency and a set of GABA(A) receptor genes. Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing.

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