Development of 3D in Vitro Technology for Medical Applications

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2014 Oct 10

PMID 25299693

Citations 30

Authors

Keng-Liang Ou

Hossein Hosseinkhani

Affiliations

Soon will be listed here.

Abstract

In the past few years, biomaterials technologies together with significant efforts on developing biology have revolutionized the process of engineered materials. Three dimensional (3D) in vitro technology aims to develop set of tools that are simple, inexpensive, portable and robust that could be commercialized and used in various fields of biomedical sciences such as drug discovery, diagnostic tools, and therapeutic approaches in regenerative medicine. The proliferation of cells in the 3D scaffold needs an oxygen and nutrition supply. 3D scaffold materials should provide such an environment for cells living in close proximity. 3D scaffolds that are able to regenerate or restore tissue and/or organs have begun to revolutionize medicine and biomedical science. Scaffolds have been used to support and promote the regeneration of tissues. Different processing techniques have been developed to design and fabricate three dimensional scaffolds for tissue engineering implants. Throughout the chapters we discuss in this review, we inform the reader about the potential applications of different 3D in vitro systems that can be applied for fabricating a wider range of novel biomaterials for use in tissue engineering.

Citing Articles

Biocompatible scaffolds based on collagen and oxidized dextran for endothelial cell survival and function in tissue engineering.

Sabet Sarvestani F, Tamaddon A, Yaghoobi R, Geramizadeh B, Azarpira N Eng Life Sci. 2023; 23(7):2200140.

PMID: 37408870 PMC: 10317976. DOI: 10.1002/elsc.202200140.

Gene Therapy for Regenerative Medicine.

Hosseinkhani H, Domb A, Sharifzadeh G, Nahum V Pharmaceutics. 2023; 15(3).

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Resveratrol Mitigates Oxygen and Glucose Deprivation-Induced Inflammation, NLRP3 Inflammasome, and Oxidative Stress in 3D Neuronal Culture.

Chiang M, Nicol C, Lo S, Hung S, Wang C, Lin C Int J Mol Sci. 2022; 23(19).

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Cartilage Regeneration Regulated by a Hydrostatic Pressure Bioreactor Based on Hybrid Photocrosslinkable Hydrogels.

Zhao X, Hua Y, Wang T, Ci Z, Zhang Y, Wang X Front Bioeng Biotechnol. 2022; 10:916146.

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Microstructural and in-vitro characteristics of functional calcium silicate topcoat on hydroxyapatite coating for bio-implant applications.

Singh J, Chatha S, Singh H Prog Biomater. 2022; 11(1):95-108.

PMID: 35191003 PMC: 8927532. DOI: 10.1007/s40204-022-00183-w.

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