Flow Cytometry and Solid Organ Transplantation: a Perfect Match

Overview

Journal Immunol Invest

Publisher Informa Healthcare

Specialty Allergy & Immunology

Date 2014 Oct 9

PMID 25296232

Citations 5

Authors

Orla Maguire

Joseph D Tario Jr

Thomas C Shanahan

Paul K Wallace

Hans Minderman

Affiliations

Soon will be listed here.

Abstract

In the field of transplantation, flow cytometry serves a well-established role in pre-transplant crossmatching and monitoring immune reconstitution following hematopoietic stem cell transplantation. The capabilities of flow cytometers have continuously expanded and this combined with more detailed knowledge of the constituents of the immune system, their function and interaction and newly developed reagents to study these parameters have led to additional utility of flow cytometry-based analyses, particularly in the post-transplant setting. This review discusses the impact of flow cytometry on managing alloantigen reactions, monitoring opportunistic infections and graft rejection and gauging immunosuppression in the context of solid organ transplantation.

Citing Articles

Development of the Crossmatch Test in Kidney Transplantation Up to the Virtual Level.

Katalinic N, Crnic Marcetic T, Trobonjaca Z, Barin-Turica F, Balen S J Clin Med. 2025; 14(4).

PMID: 40004818 PMC: 11856696. DOI: 10.3390/jcm14041288.

Crossmatch assays in transplantation: Physical or virtual?: A review.

Rocha Y, Jaramillo A, Neumann J, Hacke K, Palou E, Torres J Medicine (Baltimore). 2023; 102(50):e36527.

PMID: 38115324 PMC: 10727546. DOI: 10.1097/MD.0000000000036527.

Case Report: A five-year follow up after pediatric renal transplantation using flow cytometry crossmatch and HLA immunophenotyping based on DNA for screening test.

Dwi Meiyanto J, Daryanto B, Seputra K F1000Res. 2021; 10:352.

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Advances in single-cell sequencing: insights from organ transplantation.

Wang Y, Wang J, Schnieke A, Fischer K Mil Med Res. 2021; 8(1):45.

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Differential T Cell Signaling Pathway Activation by Tacrolimus and Belatacept after Kidney Transplantation: Post Hoc Analysis of a Randomised-Controlled Trial.

Kannegieter N, Hesselink D, Dieterich M, de Graav G, Kraaijeveld R, Baan C Sci Rep. 2017; 7(1):15135.

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