Texaphyrins and Water-soluble Zinc(II) Ionophores: Development, Mechanism of Anticancer Activity, and Synergistic Effects

Overview

Journal Bioinorg React Mech

Publisher De Gruyter

Date 2014 Oct 9

PMID 25295224

Authors

Christian Preihs

Darren J Magda

Jonathan L Sessler

Affiliations

Soon will be listed here.

Abstract

Texaphyrins, first prepared by Sessler and coworkers in the 1980s, represent early examples of expanded porphyrins. This class of pentaaza, oligopyrrolic macrocycles demonstrates excellent tumor localization and metal-chelating properties. In biological milieus, texaphyrins act as redox mediators and are able to produce reactive oxygen species. Furthermore, texaphyrins have been shown to upregulate zinc , an important feature that inspired us to develop new zinc ionophores that might allow the same function to be elicited but via a simpler chemical means. In this review, the basic properties of texaphyrins and the zinc ionophores they helped spawn will be discussed in the cadre of developing an understanding that could lead to the preparation of new, redox-active anticancer agents.

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