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Crystal Structure of the Vitamin B3 Transporter PnuC, a Full-length SWEET Homolog

Overview
Journal Nat Struct Mol Biol
Specialties Cell Biology
Molecular Biology
Date 2014 Oct 8
PMID 25291599
Citations 19
Authors
Michael Jaehme
Albert Guskov
Dirk Jan Slotboom
Affiliations
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Abstract

PnuC transporters catalyze cellular uptake of the NAD+ precursor nicotinamide riboside (NR) and belong to a large superfamily that includes the SWEET sugar transporters. We present a crystal structure of Neisseria mucosa PnuC, which adopts a highly symmetrical fold with 3+1+3 membrane topology not previously observed in any protein. The high symmetry of PnuC with a single NR bound in the center suggests a simple alternating-access translocation mechanism.

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