Suprabasin As a Novel Tumor Endothelial Cell Marker

Overview

Journal Cancer Sci

Specialty Oncology

Date 2014 Oct 7

PMID 25283635

Citations 23

Authors

Mohammad T Alam

Hiroko Nagao-Kitamoto

Noritaka Ohga

Kosuke Akiyama

Nako Maishi

Taisuke Kawamoto

Nobuo Shinohara

Akinobu Taketomi

Masanobu Shindoh

Yasuhiro Hida

Kyoko Hida

Affiliations

Soon will be listed here.

Abstract

Recent studies have reported that stromal cells contribute to tumor progression. We previously demonstrated that tumor endothelial cells (TEC) characteristics were different from those of normal endothelial cells (NEC). Furthermore, we performed gene profile analysis in TEC and NEC, revealing that suprabasin (SBSN) was upregulated in TEC compared with NEC. However, its role in TEC is still unknown. Here we showed that SBSN expression was higher in isolated human and mouse TEC than in NEC. SBSN knockdown inhibited the migration and tube formation ability of TEC. We also showed that the AKT pathway was a downstream factor of SBSN. These findings suggest that SBSN is involved in the angiogenic potential of TEC and may be a novel TEC marker.

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