Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 May 27

PMID 37240148

Authors

Zufeng Wang

Chengliang Luo

Edward W Zhou

Aaron F Sandhu

Xiaojing Yuan

George E Williams

Jialu Cheng

Bharati Sinha

Mohammed Akbar

Pallab Bhattacharya

Shuanhu Zhou

Byoung-Joon Song

Xin Wang

Affiliations

Soon will be listed here.

Abstract

The increasing comorbidity of alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) associated with traumatic brain injury (TBI) is a serious medical, economic, and social issue. However, the molecular toxicology and pathophysiological mechanisms of comorbid AUD and PTSD are not well understood and the identification of the comorbidity state markers is significantly challenging. This review summarizes the main characteristics of comorbidity between AUD and PTSD (AUD/PTSD) and highlights the significance of a comprehensive understanding of the molecular toxicology and pathophysiological mechanisms of AUD/PTSD, particularly following TBI, with a focus on the role of metabolomics, inflammation, neuroendocrine, signal transduction pathways, and genetic regulation. Instead of a separate disease state, a comprehensive examination of comorbid AUD and PTSD is emphasized by considering additive and synergistic interactions between the two diseases. Finally, we propose several hypotheses of molecular mechanisms for AUD/PTSD and discuss potential future research directions that may provide new insights and translational application opportunities.

Citing Articles

Neurologic Injury-Related Predisposing Factors of Post-Traumatic Stress Disorder: A Critical Examination.

Gillam W, Godbole N, Sangam S, DeTommaso A, Foreman M, Lucke-Wold B Biomedicines. 2023; 11(10).

PMID: 37893106 PMC: 10604790. DOI: 10.3390/biomedicines11102732.

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