Electroacoustic Stimulation: Now and into the Future

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2014 Oct 3

PMID 25276779

Citations 13

Authors

S Irving

L Gillespie

R Richardson

D Rowe

J B Fallon

A K Wise

Affiliations

Soon will be listed here.

Abstract

Cochlear implants have provided hearing to hundreds of thousands of profoundly deaf people around the world. Recently, the eligibility criteria for cochlear implantation have been relaxed to include individuals who have some useful residual hearing. These recipients receive inputs from both electric and acoustic stimulation (EAS). Implant recipients who can combine these hearing modalities demonstrate pronounced benefit in speech perception, listening in background noise, and music appreciation over implant recipients that rely on electrical stimulation alone. The mechanisms bestowing this benefit are unknown, but it is likely that interaction of the electric and acoustic signals in the auditory pathway plays a role. Protection of residual hearing both during and following cochlear implantation is critical for EAS. A number of surgical refinements have been implemented to protect residual hearing, and the development of hearing-protective drug and gene therapies is promising for EAS recipients. This review outlines the current field of EAS, with a focus on interactions that are observed between these modalities in animal models. It also outlines current trends in EAS surgery and gives an overview of the drug and gene therapies that are clinically translatable and may one day provide protection of residual hearing for cochlear implant recipients.

Citing Articles

GelMA/PEDOT:PSS Composite Conductive Hydrogel-Based Generation and Protection of Cochlear Hair Cells through Multiple Signaling Pathways.

Tan F, Li X, Li X, Xu M, Shahzad K, Hou L Biomolecules. 2024; 14(1).

PMID: 38254695 PMC: 10812993. DOI: 10.3390/biom14010095.

Preclinical evaluation of a tool for insertion force measurements in cochlear implant surgery.

Bottcher-Rebmann G, Schell V, Zuniga M, Salcher R, Lenarz T, Rau T Int J Comput Assist Radiol Surg. 2023; 18(11):2117-2124.

PMID: 37310560 PMC: 10589184. DOI: 10.1007/s11548-023-02975-2.

Models of Cochlea Used in Cochlear Implant Research: A Review.

Hrncirik F, Roberts I, Sevgili I, Swords C, Bance M Ann Biomed Eng. 2023; 51(7):1390-1407.

PMID: 37087541 PMC: 10264527. DOI: 10.1007/s10439-023-03192-3.

Improving disease prevention, diagnosis, and treatment using novel bionic technologies.

Manero A, Crawford K, Prock-Gibbs H, Shah N, Gandhi D, Coathup M Bioeng Transl Med. 2023; 8(1):e10359.

PMID: 36684104 PMC: 9842045. DOI: 10.1002/btm2.10359.

Anatomical Variations of the Human Cochlea Using an Image Analysis Tool.

Hussain R, Frater A, Calixto R, Karoui C, Margeta J, Wang Z J Clin Med. 2023; 12(2).

PMID: 36675438 PMC: 9867191. DOI: 10.3390/jcm12020509.

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