Novel Staphylococcal Species That Form Part of a Staphylococcus Aureus-related Complex: the Non-pigmented Staphylococcus Argenteus Sp. Nov. and the Non-human Primate-associated Staphylococcus Schweitzeri Sp. Nov

Overview

Journal Int J Syst Evol Microbiol

Specialty Microbiology

Date 2014 Oct 2

PMID 25269845

Citations 98

Authors

Steven Y C Tong

Frieder Schaumburg

Matthew J Ellington

Jukka Corander

Bruno Pichon

Fabian Leendertz

Stephen D Bentley

Julian Parkhill

Deborah C Holt

Georg Peters

Philip M Giffard

Affiliations

Soon will be listed here.

Abstract

We define two novel species of the genus Staphylococcus that are phenotypically similar to and have near identical 16S rRNA gene sequences to Staphylococcus aureus. However, compared to S. aureus and each other, the two species, Staphylococcus argenteus sp. nov. (type strain MSHR1132(T) = DSM 28299(T) = SSI 89.005(T)) and Staphylococcus schweitzeri sp. nov. (type strain FSA084(T) = DSM 28300(T) = SSI 89.004(T)), demonstrate: 1) at a whole-genome level considerable phylogenetic distance, lack of admixture, average nucleotide identity <95 %, and inferred DNA-DNA hybridization <70 %; 2) different profiles as determined by MALDI-TOF MS; 3) a non-pigmented phenotype for S. argenteus sp. nov.; 4) S. schweitzeri sp. nov. is not detected by standard nucA PCR; 5) distinct peptidoglycan types compared to S. aureus; 6) a separate ecological niche for S. schweitzeri sp. nov.; and 7) a distinct clinical disease profile for S. argenteus sp. nov. compared to S. aureus.

Citing Articles

Methicillin-Resistant : The Shifting Landscape in the United Arab Emirates.

Boucherabine S, Nassar R, Mohamed L, Habous M, Nabi A, Husain R Antibiotics (Basel). 2025; 14(1).

PMID: 39858310 PMC: 11759823. DOI: 10.3390/antibiotics14010024.

Antibacterial Potential of Honeybee Venom and Extracellular Metabolites Against Multidrug-Resistant Pathogenic Bacteria.

Teiba I, Mazrou Y, Makhlouf A, Nehela Y, Mohamed A, Abbas A Biology (Basel). 2025; 14(1).

PMID: 39857252 PMC: 11759185. DOI: 10.3390/biology14010021.

Tandem mobilization of anti-phage defenses alongside SCCmec elements in staphylococci.

Hossain M, Aslan B, Hatoum-Aslan A Nat Commun. 2024; 15(1):8820.

PMID: 39394251 PMC: 11470126. DOI: 10.1038/s41467-024-53146-z.

Successful treatment of sequence type 2198 uncomplicated bacteremia with a 2-week antibiotic course.

Okumura N, Kutsuna S, Tsukada A, Mezaki K, Nagashima M, Ohmagari N IJID Reg. 2024; 13:100443.

PMID: 39386113 PMC: 11462222. DOI: 10.1016/j.ijregi.2024.100443.

A Novel Approach Based on Real-Time PCR with High-Resolution Melting Analysis for the Simultaneous Identification of and .

Chieffi D, Bongiorno D, Licitra A, Campanile F, Fusco V Foods. 2024; 13(18).

PMID: 39335932 PMC: 11431256. DOI: 10.3390/foods13183004.

References

Holt D, Holden M, Tong S, Castillo-Ramirez S, Clarke L, Quail M . A very early-branching Staphylococcus aureus lineage lacking the carotenoid pigment staphyloxanthin. Genome Biol Evol. 2011; 3:881-95. PMC: 3175761. DOI: 10.1093/gbe/evr078. View

Schleifer K, Kandler O . Peptidoglycan types of bacterial cell walls and their taxonomic implications. Bacteriol Rev. 1972; 36(4):407-77. PMC: 408328. DOI: 10.1128/br.36.4.407-477.1972. View

Cheng L, Connor T, Siren J, Aanensen D, Corander J . Hierarchical and spatially explicit clustering of DNA sequences with BAPS software. Mol Biol Evol. 2013; 30(5):1224-8. PMC: 3670731. DOI: 10.1093/molbev/mst028. View

Ruimy R, Angebault C, Djossou F, Dupont C, Epelboin L, Jarraud S . Are host genetics the predominant determinant of persistent nasal Staphylococcus aureus carriage in humans?. J Infect Dis. 2010; 202(6):924-34. DOI: 10.1086/655901. View

Meier-Kolthoff J, Auch A, Klenk H, Goker M . Genome sequence-based species delimitation with confidence intervals and improved distance functions. BMC Bioinformatics. 2013; 14:60. PMC: 3665452. DOI: 10.1186/1471-2105-14-60. View

McDonald M, Dougall A, Holt D, Huygens F, Oppedisano F, Giffard P . Use of a single-nucleotide polymorphism genotyping system to demonstrate the unique epidemiology of methicillin-resistant Staphylococcus aureus in remote aboriginal communities. J Clin Microbiol. 2006; 44(10):3720-7. PMC: 1594797. DOI: 10.1128/JCM.00836-06. View

Brennan L, Lilliebridge R, Cheng A, Giffard P, Currie B, Tong S . Community-associated meticillin-resistant Staphylococcus aureus carriage in hospitalized patients in tropical northern Australia. J Hosp Infect. 2013; 83(3):205-11. DOI: 10.1016/j.jhin.2012.10.014. View

Akobi B, Aboderin O, Sasaki T, Shittu A . Characterization of Staphylococcus aureus isolates from faecal samples of the Straw-Coloured Fruit Bat (Eidolon helvum) in Obafemi Awolowo University (OAU), Nigeria. BMC Microbiol. 2012; 12:279. PMC: 3554579. DOI: 10.1186/1471-2180-12-279. View

Richter M, Rossello-Mora R . Shifting the genomic gold standard for the prokaryotic species definition. Proc Natl Acad Sci U S A. 2009; 106(45):19126-31. PMC: 2776425. DOI: 10.1073/pnas.0906412106. View

10.

Schaumburg F, Alabi A, Kock R, Mellmann A, Kremsner P, Boesch C . Highly divergent Staphylococcus aureus isolates from African non-human primates. Environ Microbiol Rep. 2013; 4(1):141-6. DOI: 10.1111/j.1758-2229.2011.00316.x. View

11.

Schleifer K, Geyer U, Kilpper-Balz R, Devriese L . Elevation of Staphylococcus sciuri subsp. lentus (Kloos et al.) to Species Status: Staphylococcus lentus (Kloos et al.) comb. nov. Syst Appl Microbiol. 2012; 4(3):382-7. DOI: 10.1016/S0723-2020(83)80022-8. View

12.

Brakstad O, Aasbakk K, Maeland J . Detection of Staphylococcus aureus by polymerase chain reaction amplification of the nuc gene. J Clin Microbiol. 1992; 30(7):1654-60. PMC: 265359. DOI: 10.1128/jcm.30.7.1654-1660.1992. View

13.

Goris J, Konstantinidis K, Klappenbach J, Coenye T, Vandamme P, Tiedje J . DNA-DNA hybridization values and their relationship to whole-genome sequence similarities. Int J Syst Evol Microbiol. 2007; 57(Pt 1):81-91. DOI: 10.1099/ijs.0.64483-0. View

14.

Tong S, Sharma-Kuinkel B, Thaden J, Whitney A, Yang S, Mishra N . Virulence of endemic nonpigmented northern Australian Staphylococcus aureus clone (clonal complex 75, S. argenteus) is not augmented by staphyloxanthin. J Infect Dis. 2013; 208(3):520-7. PMC: 3699000. DOI: 10.1093/infdis/jit173. View

15.

Svec P, Vancanneyt M, Sedlacek I, Engelbeen K, Stetina V, Swings J . Reclassification of Staphylococcus pulvereri Zakrzewska-Czerwinska et al. 1995 as a later synonym of Staphylococcus vitulinus Webster et al. 1994. Int J Syst Evol Microbiol. 2004; 54(Pt 6):2213-2215. DOI: 10.1099/ijs.0.63080-0. View

16.

Zakrzewska-Czerwinska J, Lis B, Gamian A, MORDARSKI M . Staphylococcus pulvereri sp. nov., isolated from human and animal specimens. Int J Syst Bacteriol. 1995; 45(1):169-72. DOI: 10.1099/00207713-45-1-169. View

17.

Jenney A, Holt D, Ritika R, Southwell P, Pravin S, Buadromo E . The clinical and molecular epidemiology of Staphylococcus aureus infections in Fiji. BMC Infect Dis. 2014; 14:160. PMC: 3998116. DOI: 10.1186/1471-2334-14-160. View

18.

Ng J, Holt D, Lilliebridge R, Stephens A, Huygens F, Tong S . Phylogenetically distinct Staphylococcus aureus lineage prevalent among indigenous communities in northern Australia. J Clin Microbiol. 2009; 47(7):2295-300. PMC: 2708510. DOI: 10.1128/JCM.00122-09. View

19.

Tong S, Lilliebridge R, Bishop E, Cheng A, Holt D, McDonald M . Clinical correlates of Panton-Valentine leukocidin (PVL), PVL isoforms, and clonal complex in the Staphylococcus aureus population of Northern Australia. J Infect Dis. 2010; 202(5):760-9. DOI: 10.1086/655396. View