Genomic Analysis and Identification of a Novel Superantigen, SargEY, in Isolated from Atopic Dermatitis Lesions

Overview

Journal mSphere

Publisher American Society for Microbiology

Specialties Microbiology
Parasitology

Date 2024 Jul 11

PMID 38990001

Authors

Fatkhanuddin Aziz

Junzo Hisatsune

Hisaya K Ono

Junko Kajimura

Liansheng Yu

Kanako Masuda

Hiroki Kitagawa

Yusuke Satoo

Koji Yahara

Mika Yamaoka

Akio Nakane

Hiroshi Kawasaki

Shoko Obata

Ayano Fukushima-Nomura

Yoshihiro Ito

Meiji Soe Aung

Masayuki Amagai

Siti Isrina Oktavia Salasia

Hiroki Ohge

Yoichiro Kusunoki

Motoyuki Sugai

Affiliations

Soon will be listed here.

Abstract

Importance: is frequently isolated from active lesions of atopic dermatitis (AD) patients. We reported that 17%-22% of isolated from AD patients produced a novel superantigen staphylococcal enterotoxin Y (SEY). Unlike many . superantigens that activate T cells via T-cell receptor (TCR) Vß, SEY activates T cells via TCR Vα and stimulates cytokine secretion. was isolated from AD patients during the surveillance for . Phylogenetic comparison of the genome indicated that the isolate was very similar to causing skin infections. The isolate encoded a SEY-like protein, designated SargEY, which, like SEY, activated T cells via the TCR Vα. ST2250 is the only lineage positive for SargEY gene. ST2250 harboring a superantigen SargEY gene may be a novel staphylococcal clone that infects human skin and is involved in the exacerbation of AD.

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