Controlling Bacterial Behavior with Indole-containing Natural Products and Derivatives

Overview

Journal Tetrahedron

Specialty Chemistry

Date 2014 Oct 1

PMID 25267859

Citations 21

Authors

Roberta J Melander

Marine J Minvielle

Christian Melander

Affiliations

Soon will be listed here.

Abstract

Indole has recently been implicated as an important small molecule signal utilized by many bacteria to coordinate various forms of behavior. Indole plays a role in numerous bacterial processes, including: biofilm formation and maintenance, virulence factor production, antibiotic resistance and persister cell formation. Intercepting indole-signaling pathways with appropriately designed small molecules provides a n opportunity to control unwanted bacterial behaviors, and is an attractive anti-virulence therapeutic strategy. In this review, we give an overview of the process controlled by indole signaling, and summarize current efforts to design indole-containing small molecules to intercept these pathways, and detail the synthetic efforts towards accessing indole derived bioactive small molecules.

Citing Articles

Modulation of virulence and metabolic profiles in under indole-mediated stress response.

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Three-Coordinate Iron(0) Complex-Catalyzed Regioselective C-H Alkylation of Indole Derivatives.

Zhang Z, Golling S, Cattani S, Chen X, Ackermann L J Am Chem Soc. 2025; 147(8):6897-6904.

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Downregulation of Klebsiella pneumoniae RND efflux pump genes following indole signal produced by Escherichia coli.

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Navigating contradictions: Typhimurium chemotactic responses to conflicting effector stimuli.

Franco K, Gentry-Lear Z, Shavlik M, Harms M, Baylink A bioRxiv. 2024; .

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Proteomics and metabolomics analyses of Streptococcus agalactiae isolates from human and animal sources.

Enany S, Tartor Y, Kishk R, Gadallah A, Ahmed E, Magdeldin S Sci Rep. 2023; 13(1):20980.

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