Recent Advances in Natural Product Discovery

Overview

Journal Curr Opin Biotechnol

Publisher Elsevier

Specialty Biotechnology

Date 2014 Sep 27

PMID 25260043

Citations 66

Authors

Yunzi Luo

Ryan E Cobb

Huimin Zhao

Affiliations

Soon will be listed here.

Abstract

Natural products have been and continue to be the source and inspiration for a substantial fraction of human therapeutics. Although the pharmaceutical industry has largely turned its back on natural product discovery efforts, such efforts continue to flourish in academia with promising results. Natural products have traditionally been identified from a top-down perspective, but more recently genomics- and bioinformatics-guided bottom-up approaches have provided powerful alternative strategies. Here we review recent advances in natural product discovery from both angles, including diverse sampling and innovative culturing and screening approaches, as well as genomics-driven discovery and genetic manipulation techniques for both native and heterologous expression.

Citing Articles

Bioactive Compounds Produced by Endophytic Bacteria and Their Plant Hosts-An Insight into the World of Chosen Herbaceous Ruderal Plants in Central Europe.

Drozdzynski P, Rutkowska N, Rodziewicz M, Marchut-Mikolajczyk O Molecules. 2024; 29(18).

PMID: 39339451 PMC: 11433698. DOI: 10.3390/molecules29184456.

Discovering New Natural Products Using Metabolomics-Based Approaches.

de Medeiros L, de Araujo Junior M, Peres E, Carlos Ipuchima da Silva J, Bassicheto M, Di Gioia G Adv Exp Med Biol. 2023; 1439:185-224.

PMID: 37843810 DOI: 10.1007/978-3-031-41741-2_8.

Functional Crosstalk between Discrete Indole Terpenoid Gene Clusters in .

Hibbard T, McLellan R, Stevenson L, Richardson A, Nicholson M, Parker E Org Lett. 2023; 25(41):7470-7475.

PMID: 37797949 PMC: 10595974. DOI: 10.1021/acs.orglett.3c02412.

Genome Mining and Screening for Secondary Metabolite Production in the Endophytic Fungus CT-6.

Ming Q, Huang X, He Y, Qin L, Tang Y, Liu Y Microorganisms. 2023; 11(4).

PMID: 37110391 PMC: 10142127. DOI: 10.3390/microorganisms11040968.

Generation of a high quality library of bioactive filamentous actinomycetes from extreme biomes using a culture-based bioprospecting strategy.

Swiecimska M, Golinska P, Goodfellow M Front Microbiol. 2023; 13:1054384.

PMID: 36741889 PMC: 9893292. DOI: 10.3389/fmicb.2022.1054384.

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