Orexin-A Controls Sympathetic Activity and Eating Behavior

Overview

Journal Front Psychol

Date 2014 Sep 25

PMID 25250003

Citations 42

Authors

Giovanni Messina

Carmine Dalia

Domenico Tafuri

Vincenzo Monda

Filomena Palmieri

Amelia Dato

Angelo Russo

Saverio De Blasio

Antonietta Messina

Vincenzo De Luca

Sergio Chieffi

Marcellino Monda

Affiliations

Soon will be listed here.

Abstract

It is extremely important for the health to understand the regulatory mechanisms of energy expenditure. These regulatory mechanisms play a central role in the pathogenesis of body weight alteration. The hypothalamus integrates nutritional information derived from all peripheral organs. This region of the brain controls hormonal secretions and neural pathways of the brainstem. Orexin-A is a hypothalamic neuropeptide involved in the regulation of feeding behavior, sleep-wakefulness rhythm, and neuroendocrine homeostasis. This neuropeptide is involved in the control of the sympathetic activation, blood pressure, metabolic status, and blood glucose level. This minireview focuses on relationship between the sympathetic nervous system and orexin-A in the control of eating behavior and energy expenditure. The "thermoregulatory hypothesis" of food intake is analyzed, underlining the role played by orexin-A in the control of food intake related to body temperature. Furthermore, the paradoxical eating behavior induced orexin-A is illustrated in this minireview.

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