The Common Fragile Site FRA16D Gene Product WWOX: Roles in Tumor Suppression and Genomic Stability

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2014 Sep 24

PMID 25245215

Citations 24

Authors

Rami I Aqeilan

Muhannad Abu-Remaileh

Mohammad Abu-Odeh

Affiliations

Soon will be listed here.

Abstract

The fragile WWOX gene, encompassing the chromosomal fragile site FRA16D, is frequently altered in human cancers. While vulnerable to DNA damage itself, recent evidence has shown that the WWOX protein is essential for proper DNA damage response (DDR). Furthermore, the gene product, WWOX, has been associated with multiple protein networks, highlighting its critical functions in normal cell homeostasis. Targeted deletion of Wwox in murine models suggests its in vivo requirement for proper growth, metabolism, and survival. Recent molecular and biochemical analyses of WWOX functions highlighted its role in modulating aerobic glycolysis and genomic stability. Cumulatively, we propose that the gene product of FRA16D, WWOX, is a functionally essential protein that is required for cell homeostasis and that its deletion has important consequences that contribute to the neoplastic process. This review discusses the essential role of WWOX in tumor suppression and genomic stability and how its alteration contributes to cancer transformation.

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